Results 91 to 100 of about 136,601 (268)

Metagenome sequencing and 982 microbial genomes from Kermadec and Diamantina Trenches sediments

open access: yesScientific Data
Deep-sea trenches representing an intriguing ecosystem for exploring the survival and evolutionary strategies of microbial communities in the highly specialized deep-sea environments.
Yingdong Li   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Exploring the Effects of Internal and External Factors on the Early Growth of Anchovy (Engraulis japonicus) in the Yellow Sea Based on Otolith Microstructure

open access: yesProgress in Fishery Sciences
The abundant and widely distributed resources of small pelagic fish in marine ecosystems constitute significant targets for commercial fisheries. The Japanese anchovy (Engraulis japonicus) is a prominent representative of small pelagic fish and is ...
Wenwen WANG   +6 more
doaj   +1 more source

Submarine canyons influence macrofaunal diversity and density patterns in the deep-sea benthos

open access: green, 2020
C. Robertson   +10 more
openalex   +2 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Variance Component Estimation (VCE)-Based Adaptive Stochastic Modeling for Enhanced Convergence and Robustness in GNSS Precise Point Positioning (PPP)

open access: yesRemote Sensing
The stochastic model in Precise Point Positioning (PPP) defines the statistical properties of observations and the dynamic behavior of parameters. An inaccurate stochastic model can degrade positioning accuracy, ambiguity resolution, and other aspects of
Yanning Zheng   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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