Results 91 to 100 of about 103,225 (263)
Polish Maritime ResearchSolar-powered autonomous underwater vehicles (SAUVs) can harness sustainable natural energy, meaning that they are capable of providing long-term mission support. This paper describes ongoing development work on the overall design of a SAUV.
Yu Chunliang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Open Encyclopedia of AnthropologyThe mystery evoked by the deep sea—its darkness, remoteness, and inaccessibility—has long captivated the public imagination. Iconic works of science fiction as well as pioneering documentaries reflect a fascination with unveiling the unknown; this spirit of discovery, of bringing light into the depths, remains alive today and has arguably even ...
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Geochemistry, Geophysics, GeosystemsFe‐oxidizing microorganisms in deep‐sea hydrothermal vent environments are often used as analogs for primordial life on Earth. In fact, Earth's oldest purported microfossils are preserved as hematite filaments in a jasper rock dated between 4,160 and 4 ...
Dominic Papineau +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Progress in Fishery SciencesThe abundant and widely distributed resources of small pelagic fish in marine ecosystems constitute significant targets for commercial fisheries. The Japanese anchovy (Engraulis japonicus) is a prominent representative of small pelagic fish and is ...
Wenwen WANG +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source