Results 121 to 130 of about 1,292,419 (308)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A Depth-Aware HGNN Method and Its Application in Anomaly Detection and Correction of Sparse Ocean Sensor Data

Sensors
In the field of ocean observation, we often face the challenge of the contradiction between the vast ocean environment and limited ocean sensor observations, resulting in significant sparsity in the acquired ocean sensor data.
Zongxun Han, Xiang Gao, Zhengbao Li, Yugang Ren, Xianpeng Shi   +4 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Intermediate depth and deep earthquakes: complexity of the Ibero-Magrhebian region [PDF]

, 2010
The Ibero-Magrhebian region is located at the plate boundary between Eurasia and Africa and it is a tectonically complex region.
Bezzeghoud, M., Buforn, E., Cesca, S., del Fresno, C., Udias, A.   +4 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Recent results from the ANTARES deep sea neutrino telescope

, 2012
The ANTARES deep sea neutrino telescope has acquired over four years of high quality data. This data has been used to measure the oscillation parameters of atmospheric neutrinos and also to search for neutrinos of a non-terrestrial origin.
Coyle, Paschal
core   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Iron is an important influence of volcanic ash input on the evolution of deep-sea ecosystems

Microbiology Spectrum
Volcanoes, originating from deep-seated magmatic activity, serve as crucial conduits connecting Earth’s interior and surface. Volcanic eruptions, a primary manifestation of this connection, exert profound influence across Earth’s surface systems ...
Shijie Bai, Zijia Wang, Yuang Guo, Hengchao Xu, Jiwei Li, Xiaotong Peng   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Deep sea

Open Encyclopedia of Anthropology
The mystery evoked by the deep sea—its darkness, remoteness, and inaccessibility—has long captivated the public imagination. Iconic works of science fiction as well as pioneering documentaries reflect a fascination with unveiling the unknown; this spirit of discovery, of bringing light into the depths, remains alive today and has arguably even ...
openaire   +1 more source