Results 121 to 130 of about 204,461 (310)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Diversity of meiofauna at deep-sea hydrothermal vents and cold seeps with particular reference to nematodes

, 2007
Deep-sea hydrothermal vents and cold seeps are remarkable for their spectacular megaandmacrofauna, many of which appear to have a high level of endemism to these chemosyntheticenvironments.
Flint, Hannah Christina
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ferride composition of deep sea cores obtained during the Swedish Deep-Sea Expedition

, 1966
Ferride composition of deep sea cores obtained during the Swedish Deep-Sea ...
Sture Landergren (6965036), Landergren, Sture   +1 more
core   +1 more source

A Depth-Aware HGNN Method and Its Application in Anomaly Detection and Correction of Sparse Ocean Sensor Data

Sensors
In the field of ocean observation, we often face the challenge of the contradiction between the vast ocean environment and limited ocean sensor observations, resulting in significant sparsity in the acquired ocean sensor data.
Zongxun Han, Xiang Gao, Zhengbao Li, Yugang Ren, Xianpeng Shi   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Major constituents of deep sea cores obtained during the Swedish Deep-Sea Expedition

, 1966
Major constituents of deep sea cores obtained during the Swedish Deep-Sea ...
Sture Landergren (6965036), Landergren, Sture   +1 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Iron is an important influence of volcanic ash input on the evolution of deep-sea ecosystems

Microbiology Spectrum
Volcanoes, originating from deep-seated magmatic activity, serve as crucial conduits connecting Earth’s interior and surface. Volcanic eruptions, a primary manifestation of this connection, exert profound influence across Earth’s surface systems ...
Shijie Bai, Zijia Wang, Yuang Guo, Hengchao Xu, Jiwei Li, Xiaotong Peng   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source