Results 71 to 80 of about 798,589 (237)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Retrieving water ice abundance in representative regions of the Moon’s South Pole using topography corrected SELENE MI images

Geoscience Letters
Previous studies have reported the existence of water ice in the lunar polar regions, but estimations of water ice using different methods vary in certainty, precision, location, and abundance.
Xindi Long, Chao Wang, Siji Sanlang, Yongjiu Feng, Xiong Xu, Huan Xie, Xiaohua Tong   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

3D Discrete element method modeling of the cone penetration test in lunar regolith simulant with various internal friction angles

Geo-spatial Information Science
The mechanical behavior of lunar regolith is highly influenced by its diverse mechanical properties, which are critical for geotechnical engineering activities during lunar exploration missions.
Siji Sanlang, Chao Wang, Xiaohua Tong, Huan Xie, Yongjiu Feng, Jia Li, Mingjing Jiang, Xiong Xu, Yanmin Jin   +8 more
doaj   +1 more source

A Control Framework for Autonomous Smart Grids for Space Power Applications [PDF]

With the National Aeronautics and Space Administration's (NASA) rising interest in lunar surface operations and deep space exploration, there is a growing need to move from traditional ground-based mission operations to more autonomous vehicle level ...
Carbone, Marc A.
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Nuclear systems for space power and propulsion [PDF]

As exploration and utilization of space proceeds through the 1970s, 1980s, and beyond, spacecraft in earth orbit will become increasingly larger, spacecraft will travel deeper into space, and space activities will involve more complex operations.
Klein, M.
core   +1 more source

Seeking a solution of the Pioneer Anomaly

, 2007
The 1972 and 1973 launched Pioneer 10 and 11 were the first missions to explore the outer solar system. They achieved stunning breakthroughs in deep-space exploration.
Anderson, John D., Nieto, Michael Martin
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Evaluation of deep space exploration risks and mitigations against radiation and microgravity. [PDF]

Front Nucl Med, 2023
Dobney W, Mols L, Mistry D, Tabury K, Baselet B, Baatout S.   +5 more
europepmc   +1 more source