Results 81 to 90 of about 798,589 (237)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Ka-band (32-GHz) downlink capability for deep space communications [PDF]

The first quarter century of U.S. solar system exploration using unmanned spacecraft has involved progressively higher operating frequencies for deep space telemetry: L-band (960 MHz) in 1962 to S-band (2.3 GHz) in 1964 to X-band (8.4 GHZ) in 1977.
Smith, J. G.
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

An embedded electron current layer observed at the edge of the plasma sheet in the Earth’s magnetotail

Earth and Planetary Physics
The formation of an embedded electron current sheet within the magnetotail plasma sheet has been poorly understood. In this article, we present an electron current layer detected at the edge of the magnetotail plasma sheet.
ChenChen Zhan, RongSheng Wang, QuanMing Lu, San Lu, XinMin Li   +4 more
doaj   +1 more source

Human behavior and performance in deep space exploration: next challenges and research gaps. [PDF]

NPJ Microgravity, 2023
Pagnini F, Manzey D, Rosnet E, Ferravante D, White O, Smith N.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Energy Conversion Associated with Intermittent Currents in the Magnetosheath Downstream of the Quasi-Parallel Shock

Magnetochemistry
Using the data from the Magnetospheric Multiscale (MMS) mission, we studied the energy conversion between electromagnetic fields and particles (ions and electrons) in a spacecraft rest frame inside a turbulent magnetosheath downstream of the quasi ...
Xinmin Li, Rongsheng Wang, San Lu, Ao Guo, Zhijian Zhang   +4 more
doaj   +1 more source

Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration. [PDF]

NPJ Microgravity, 2023
Liphardt AM, Fernandez-Gonzalo R, Albracht K, Rittweger J, Vico L.   +4 more
europepmc   +1 more source

Rational physical agent reasoning beyond logic

, 2009
The paper addresses the problem of defining a theoretical physical agent framework that satisfies practical requirements of programmability by non-programmer engineers and at the same time permitting fast realtime operation of agents on digital computer ...
Lincoln, Nick K., Veres, Sandor M.
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source