Results 161 to 170 of about 7,638,076 (261)

Cerebral Small Vessel Disease in Immune‐Mediated Thrombotic Thrombocytopenic Purpura Patients During the Acute Phase and Disease Remission

American Journal of Hematology, Volume 101, Issue 12, Page 3001-3009, December 2026.
ABSTRACT Immune‐mediated thrombotic thrombocytopenic purpura (iTTP) is a life‐threatening thrombotic microangiopathy characterized by acute neurological manifestations and long‐term sequelae related to microvascular brain injury. Cerebral small vessel disease (cSVD), detectable on MRI through lacunes, microbleeds, white matter hyperintensities, and ...
Addolorata Truma, Francesco Maria Lo Russo, Giorgio Conte, Ilaria Mancini, Andrea Artoni, Juri Alessandro Giannotta, Barbara Ferrari, Pasquale Agosti, Maria Abbattista, Matteo Gagliardi, Eleonora Piccin, Marco Stroppi, Fabio Maria Triulzi, Flora Peyvandi   +13 more
wiley   +1 more source

Cerebellar Abnormalities in the Neuroimaging Spectrum of CLTC‐Related Disorder

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2601-2607, December 2026.
ABSTRACT Pathogenic variants in CLTC, which encodes the clathrin heavy chain involved in vesicle‐mediated trafficking in neurons, cause a rare neurodevelopmental disorder associated with variable severity of global developmental delay and intellectual disability and structural brain abnormalities. Although corpus callosum and white matter anomalies are
Daniel Charouf, Andrea Accogli, Fadi F. Hamdan, Francesca Nardecchia, Toshiyuki Itai, Kenneth A. Myers, Christine Saint Martin, Myriam Srour   +7 more
wiley   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2784-2789, December 2026.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Cumulative Unfavorable Social Determinants of Health and AT(N)‐V Pathology in Relation to Cognitive Performance Among Non‐Hispanic Black Men from HABS‐HD

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 4, December 2026.
Abstract INTRODUCTION The relationship between social determinants of health (SDoH) burden, Alzheimer's disease–related neuroimaging markers, and cognitive performance among non‐Hispanic Black (NHB) men remains insufficiently characterized. METHODS We analyzed data from 331 NHB males enrolled in the Health and Aging Brain Study–Health Disparities ...
Cellas A. Hayes, Raymond Jones, Edward Ofori, Roland J. Thorpe Jr., the Health and Aging Brain Study (HABS‐HD) Study Team   +4 more
wiley   +1 more source

A Generalized Approach to Solving Deep Learning‐Based Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (QSM + qBOLD or QQ) for Oxygen Extraction Fraction (OEF) Mapping Across Diverse Acquisition Schemes

Magnetic Resonance in Medicine, Volume 96, Issue 6, Page 2812-2821, December 2026.
ABSTRACT Purpose QQ, a recently proposed oxygen extraction fraction (OEF) mapping technique combining quantitative susceptibility mapping (QSM) and quantitative blood oxygen level‐dependent (qBOLD) (QSM + qBOLD = QQ), generates OEF maps noninvasively from a single routine MRI sequence, without requiring vascular challenges used in other OEF approaches.
Tian Qiu, Ada Ally, Arpita Misra, Gloria C. Chiang, Thanh D. Nguyen, Susan A. Gauthier, Shun Zhang, Yi Wang, Junghun Cho   +8 more
wiley   +1 more source

Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease

Clinical Genetics, Volume 110, Issue 6, Page 686-694, December 2026.
Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler, Neven Maksemous, Rodney A. Lea, Robert A. Smith, Heidi G. Sutherland, Lyn R. Griffiths   +5 more
wiley   +1 more source

Memory Services for People With Down Syndrome: A Scoping Review Exploring Models of Care and Access

Journal of Policy and Practice in Intellectual Disabilities, Volume 23, Issue 4, December 2026.
ABSTRACT More than 95% of people with Down syndrome develop Alzheimer's disease (AD), with a median age of diagnosis of approximately 54 years. However, there is a significant gap in guidance regarding the design of effective memory services and tailored diagnostic pathways.
M. Healy, A. Brodtmann, A. M. Foster, D. Ayton   +3 more
wiley   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2568-2574, November 2026.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Disease progression in probable limbic‐predominant age‐related TDP‐43 encephalopathy

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA‐binding protein of 43 kDa (TDP‐43) encephalopathy (LATE) is confirmed in post mortem examination by TDP‐43 pathology. Applying certain criteria, we examined cognitive trajectories in probable LATE and Alzheimer's disease (AD) participants compared with cognitively normal (CN)
Charlotte Moss, Lei Yu, Konstatinos Arfanakis, Ajay Sood, for Alzheimer's Disease Neuroimaging Initiative   +4 more
wiley   +1 more source

Coronary artery disease and cardiac pathology in cerebral small vessel disease and post‐stroke dementia: Implications for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract BACKGROUND The relationships between coronary or cardiac pathology, cerebral small vessel disease (SVD), Alzheimer's disease pathology, and vascular cognitive impairment and dementia (VCID) remain unclear. METHODS We performed a clinicopathological study in 75 stroke patients enrolled in the prospective Cognitive Function After Stroke (CogFAST)
Yoshiki Hase, Tuomo Polvikoski, Dan Jobson, Klarizze Premarion, Ethan Tutter, Erika Kitajima, Pazhanichamy Kalailingam, Xavier Gallart‐Palau, Siu Kwan Sze, Louise Allan, Raj N. Kalaria   +10 more
wiley   +1 more source