Results 61 to 70 of about 1,902,450 (297)
Supercell calculations in the reduced Hartree-Fock model for crystals with local defects
, 2016 In this article, we study the speed of convergence of the supercell reduced Hartree-Fock~(rHF) model towards the whole space rHF model in the case where the crystal contains a local defect.
Gontier, David, Lahbabi, Salma
core +3 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Defect Sequence for Contractive Tuples
, 2012 We introduce the defect sequence for a contractive tuple of Hilbert space operators and investigate its properties. The defect sequence is a sequence of numbers, called defect dimensions associated with a contractive tuple.
Bhattacharyya, Tirthankar +2 more
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
International Journal of Electrochemical Science, 2020 Reduced graphene oxide-supported palladium nanocomposites (Pd-rGO) were synthesized by an in situ chemical reduction method. The composite nanomaterials have excellent conductivity and catalytic ability due to the synergistic effect of the two components.
Xuyan Mao +6 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Eigenfunction scarring and improvements in $L^{\infty}$ bounds
, 2018 We study the relationship between $L^\infty$ growth of eigenfunctions and their $L^2$ concentration as measured by defect measures. In particular, we show that scarring in the sense of concentration of defect measure on certain submanifolds is ...
Galkowski, Jeffrey, Toth, John A.
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Assessing the clinical application value of SNP-array in fetal central nervous system malformations
Human GenomicsBackground Single nucleotide polymorphism array (SNP-array) has been introduced for prenatal diagnosis. This study aims to evaluate the clinical utility of SNP-array in the prenatal central nervous system (CNS) malformations.
Wei Li +17 more
doaj +1 more source
Cardiology Research and Practice, 2021 Objective. We retrospectively analyzed the surgical results of pulmonary blood flow studies to guide ventricular septal defect (VSD) closure in the correction of pulmonary atresia and ventricular septal defect with major aortopulmonary collateral ...
Zirou Huang +8 more
doaj +1 more source