Results 61 to 70 of about 1,062,401 (295)

An overview on the obsolescence of physical assets for the defence facing the challenges of industry 4.0 and the new operating environments [PDF]

, 2018
Libro en Open AccessThis contribution is intended to observe special features presented in physical assets for defence. Particularly, the management of defence assets has to consider not only the reliability, availability, maintainability and other ...
Crespo Márquez, Adolfo, González-Prida, Vicente, Haugen, Stein (Coordinador), Martínez-Galán, Pablo, Villar-Fidalgo, Luis, Zamora, J.   +5 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Implications for the U.S. of Anglo-French Defense Cooperation [PDF]

, 2012
The paper analyzes, from a predominantly UK perspective, the implications for the U.S. of the November 2, 2010, Anglo-French Defence Cooperation Treaty.
Antill, Peter D., Burgess, K, Ito, Pete, Moore, David M., Young, Steve   +4 more
core   +2 more sources

Evolutionarily stable defence and signalling of that defence [PDF]

, 2006
We examine the evolution and maintenance of defence and conspicuousness in prey species using a game theoretic model. In contrast to previous works, predators can raise as well as lower their attack probabilities as a consequence of encountering ...
Adler, Björkman, Bowers, Bowers, Brodie, Camara, Cohen, Dobler, Endler, G.D. Ruxton, Gamberale-Stille, Grill, Harvey, Irie, Iwasa, Karban, Kearsley, Leimar, M. Broom, M.P. Speed, Mallet, Merilaita, Pearce, Roper, Rowell-Rahier, Ruxton, Servedio, Sherratt, Shudo, Shudo, Shudo, Speed, Speed, Summers, VanDam, Wallace, Yachi, Zalucki   +37 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

La poliorcética de los castillos medievales de la Región de Murcia

Alejandría, 2022
In the following article, we address the subject related to the poliorcetica of some of the main castles of the Region of Murcia, although the medieval period presents a wide arc; in this article we focus mainly on addressing the poliorcetica referring ...
Rubén Marco Cano
doaj  

Evolution of Political and Security Relationship between the Republic of Poland and the United States of America in the years 1999–2019

Journal on Baltic Security, 2020
The article discusses the evolution of political and security cooperation between the Republic of Poland and the United States of America in the years 1999–2019.
Kozlowski Grzegorz
doaj   +1 more source

Turning defence into offence? Intrusion of cladoceran brood chambers by a green alga leads to reproductive failure

Royal Society Open Science, 2020
Microalgae are the foundation of aquatic food webs. Their ability to defend against grazers is paramount to their survival, and modulates their ecological functions. Here, we report a novel anti-grazer strategy in the common green alga Chlorella vulgaris
Dania Albini, Mike S. Fowler, Carole Llewellyn, Kam W. Tang   +3 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source