Research Note: Intestinal avian defensin 2 and robustness of chicks
Poultry Science: Poultry production is an important agricultural sector for human food worldwide. Chicks after hatch often face health problems leading to economic losses that are deleterious for breeders. Avian defensin 2 (AvBD2) is a prominent host defense peptide of
Sonia Métayer Coustard +8 more
doaj +1 more source
False-negative synovial alpha-defensin
Arthroplasty Today, 2017 We present a case of chronic periprosthetic hip infection diagnosed using the Musculoskeletal Infection Society criteria as the gold standard. The alpha-defensin test was falsely negative.
Jake R. Adams, MD, Adam J. Schwartz, MD
doaj +1 more source
Host factors and early treatments to restrict paediatric HIV infection and early disease progression [PDF]
, 2015 open6noA body of evidence indicates that a threshold level of the virus is required to establish systemic and persistent HIV infection in the host and that this level depends on virus-host interactions.
De Rossi, Anita +5 more
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Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial. [PDF]
, 2017 More efficacious treatment regimens are needed for tuberculosis, however, drug development is impeded by a lack of reliable biomarkers of disease severity and of treatment effect. We conducted a directed screen of host biomarkers in participants enrolled
Barbero, S +14 more
core +2 more sources
Small, EarlyView.Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome
BMC Genomics, 2009 Background Host defense peptides are a critical component of the innate immune system. Human alpha- and beta-defensin genes are subject to copy number variation (CNV) and historically the organization of mouse alpha-defensin genes has been poorly defined.
Dougan Gordon +6 more
doaj +1 more source
The Putative Role of Human Peritoneal Adipocytes in the Fight against Bacteria: Synthesis of the Antimicrobial Active Peptide DEFA1-3 [PDF]
, 2010 Background: Spontaneous peritonitis is a rather rare event, even in peritoneal dialysis (PD). As defensins are natural antimicrobial peptides, we hypothesized that adipocytes as the major constituents of the omentum could play an important role in ...
Groene, Hermann-Josef +5 more
core +1 more source
Medical Gas Plasma Inactivates Adenoviruses via Capsid Oxidation
Small, EarlyView.Oxidative modification of three adenoviral capsid proteins after gas plasma treatment. Schematic representation of the viral infection process, starting with the initial attachment of the virus via its fiber protein binding to the cellular receptors (CAR and/or CD46). In the secondary attachment step, the penton base binds to integrin structures on the
Anke Schmidt +7 more
wiley +1 more source
Comparative genomic identification and validation of β-defensin genes in the Ovis aries genome
BMC Genomics, 2017 Background β-defensins are small, cationic, antimicrobial peptides found in species across the plant and animal kingdoms. In addition to microbiocidal activity, roles in immunity as well as reproduction have more recently been documented.
T. J. Hall +5 more
doaj +1 more source
Novel Molecules for Intra-Oral Delivery of Antimicrobials to Prevent and Treat Oral Infectious Diseases [PDF]
, 2008 New molecules were designed for efficient intra-oral delivery of antimicrobials to prevent and treat oral infection. The salivary statherin fragment, which has high affinity for the tooth enamel, was used as a carrier peptide. This was linked through the
Dentino, Andrew R. +2 more
core +1 more source