Results 101 to 110 of about 37,059 (248)

Immunohistochemical study on the distribution of β-defensin 1 and β-defensin 2 throughout the respiratory tract of healthy rats [PDF]

, 2018
The distributions of β-defensin 1 and 2 in secretory host defense system throughout respiratory tract of healthy rats were immunohistochemically investigated.
Yuasa, Hideto, Hideto YUASA, Masaya ARAI, Mantani, Youhei, Yoshitomi, Chiaki, Kawano, Junichi, Junichi KAWANO, Chiaki YOSHITOMI, Arai, Masaya, Masuda, Natsumi, Nishida, Miho, Miho NISHIDA, Hoshi, Nobuhiko, Qi, Wang-Mei, Kitagawa, Hiroshi, Wang-Mei QI, Nobuhiko HOSHI, Youhei MANTANI, Yokoyama, Toshifumi, Toshifumi YOKOYAMA, Hiroshi KITAGAWA, Natsumi MASUDA   +21 more
core   +1 more source

Multi‐omics analyses reveal host–microbe interactions in atopic dermatitis and psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Atopic dermatitis (AD) and psoriasis (PSO) are chronic inflammatory skin diseases with complex host–microbe interactions. This study analysed skin samples from patients and healthy individuals using integrated microbial and transcriptomic profiling. Both diseases showed disrupted fungal–bacterial interactions and alterations in host immune responses ...
Ying Yang, Peter Olah, Alexander Salava, Jonathan Barker, Antti Lauerma, Björn Andersson, Nanna Fyhrquist, Bernhard Homey, Harri Alenius   +8 more
wiley   +1 more source

Expression pattern, promoter activity and bactericidal property of beta-defensin from the mandarin fish Siniperca chuatsi

, 2012
beta-Defensin (BD) are cysteine-rich, cationic antimicrobial peptides which play an important role in innate immune system against invading microbes.
Wang, Gailing, Xie, Haixia, Chang, MX (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China., Li, Junhua, Nie, Pin, Zou, Pengfei, Huang, Bei, Chang, Mingxian   +7 more
core   +1 more source

Pathogenesis of hidradenitis suppurativa: From susceptibility to chronicity

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review describes hidradenitis suppurativa as a heterogeneous disorder in which genetic susceptibility, epithelial dysfunction, environmental exposures, immune activation and microbial ecology converge differently across patients and disease stages.
Kelsey R. van Straalen, Nisha S. Chandran, Jean M. Fletcher, Evangelos J. Giamarellos‐Bourboulis, Elia Rosi, Gregor B. E. Jemec   +5 more
wiley   +1 more source

The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

eLife, 2019
Antimicrobial peptides (AMPs) are small cationic molecules best known as mediators of the innate defence against microbial infection. While in vitro and ex vivo evidence suggest AMPs’ capacity to kill cancer cells, in vivo demonstration of an anti-tumour
Jean-Philippe Parvy, Yachuan Yu, Anna Dostalova, Shu Kondo, Alina Kurjan, Philippe Bulet, Bruno Lemaître, Marcos Vidal, Julia B Cordero   +8 more
doaj   +1 more source

Hidradenitis suppurativa skin microbiome: In‐depth analysis and modulation by systemic therapies

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Hidradenitis suppurativa skin exhibits profound dysbiosis, characterized by the depletion of homeostatic commensals and expansion of anaerobic pathogens. Longitudinal evaluation reveals that while systemic antibiotics successfully reverse HS dysbiosis, biologics (adalimumab and secukinumab) fail to clear pathogens despite clinical healing.
Yacine Amar, Diana Baumann, Sebastian Niedermeier, Rafaela L. Silva, Susanne Walch, Michael Schloter, Martin Köberle, Tilo Biedermann, Thomas Volz   +8 more
wiley   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Inflammatory burden in dialysis patients: the role of alpha defensin

Frontiers in Immunology
IntroductionThe major neutrophilic peptide alpha-defensin plays a pivotal role in atherogenesis. Atherosclerosis is more frequent in dialysis patients, increasingly ascribed to chronic low-grade inflammation.
Maanit Shapira, Adib Abo Aqil, Ameena Zahalka, Isis Abumouch, Naama Amsalem, Rami Abu Fanne   +5 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Prognostic role of alpha defensin in predicting periprocedural major myocardial injury following elective percutaneous coronary intervention

American Heart Journal Plus
Background: Periprocedural major myocardial injury (pMMI) remains a frequent complication of elective percutaneous coronary intervention (PCI) and is incompletely explained by procedural complexity or ischemic burden alone.
A.A. Higazi, M. Shapira, I. Abumouch, E. Maraga, N. Amsalem, R. Abu Fanne   +5 more
doaj   +1 more source