Results 41 to 50 of about 54,404 (260)

Study on the Inhibitory Activity of a Synthetic Defensin Derived from Barley Endosperm against Common Food Spoilage Yeast

Molecules, 2020
In the food industry, food spoilage is a real issue that can lead to a significant amount of waste. Although current preservation techniques are being applied to reduce the occurrence of spoilage microorganisms, the problem persists.
Laila N. Shwaiki, Aylin W. Sahin, Elke K. Arendt   +2 more
doaj   +1 more source

Large-scale Synthesis and Functional Elements for the Antimicrobial Activity of Defensins [PDF]

, 2000
Human neutrophil defensins, and their analogues incorporating anionic, hydrophobic or cationic residues at the N- and C-termini, were synthesized by solid-phase procedures.
Antonyraj, K. J., Karunakaran, T., Raj, Periathamby A.   +2 more
core   +3 more sources

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Antimicrobial peptides and other potential biomarkers of critical illness in SARS‐CoV‐2 patients with acute kidney injury. AMPAKI‐CoV study

Physiological Reports
Antimicrobial peptides (AMPs) constitute a complex network of 10–100 amino acid sequence molecules widely distributed in nature. While over 300 AMPs have been described in mammals, cathelicidins and defensins remain the most extensively studied.
Lucas Ferreira Theotonio dos Santos, Hermes Vieira Barbeiro, Denise Frediani Barbeiro, Heraldo Possolo deSouza, Fabiano Pinheiro da Silva   +4 more
doaj   +1 more source

Predictive value of baseline alpha defensin level in patients with stable coronary artery disease: A retrospective single center study

International Journal of Cardiology: Heart & Vasculature
Background: Inflammation plays a central role in atherogenesis. The major neutrophilic peptide alpha-defensin is a promising evolving risk factor for atherosclerosis.
Maanit Shapira, Ariel Roguin, Ibraheem Fayad, Lina Medlij, Aysha khateeb, Dema Egbaria, Naama Amsalem, Rami Abu Fanne   +7 more
doaj   +1 more source

Membrane Permeabilization and Antimicrobial Activity of Recombinant Defensin-d2 and Actifensin against Multidrug-Resistant Pseudomonas aeruginosa and Candida albicans

Molecules, 2022
Antimicrobial resistance requires urgent efforts towards the discovery of active antimicrobials, and the development of strategies to sustainably produce them.
Ifeoluwa D. Gbala, Rosaline W. Macharia, Joel L. Bargul, Gabriel Magoma   +3 more
doaj   +1 more source

Current Status of Defensins and Their Role in Innate and Adaptive Immunity [PDF]

, 2002
Naturally occurring antimicrobial cationic polypeptides play a major role in innate and adaptive immunity. These polypeptides are found to be either linear and unstructured or structured through disulfide bonds.
Dentino, Andrew R., Raj, Periathamby A.
core   +1 more source

Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity. [PDF]

, 2017
Peptide-based supramolecular assemblies are a promising class of nanomaterials with important biomedical applications, specifically in drug delivery and tissue regeneration.
Adler-Abramovich, Lihi, Brahmachari, Sayanti, Bychenko, Darya, DeGrado, William F, Gazit, Ehud, Kolusheva, Sofiya, Mensa, Bruk, Schmidt, Nathan W, Schnaider, Lee, Shaham-Niv, Shira, Shimon, Linda JW   +10 more
core   +3 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Human β-Defensin 2 (HBD-2) Displays Oncolytic Activity but Does Not Affect Tumour Cell Migration

Biomolecules, 2022
Defensins form an integral part of the cationic host defence peptide (HDP) family, a key component of innate immunity. Apart from their antimicrobial and immunomodulatory activities, many HDPs exert multifaceted effects on tumour cells, notably direct ...
Guneet K. Bindra, Scott A. Williams, Fung T. Lay, Amy A. Baxter, Ivan K. H. Poon, Mark D. Hulett, Thanh Kha Phan   +6 more
doaj   +1 more source