Results 101 to 110 of about 6,178 (191)

Gastric ulcer in a child treated with deferasirox

, 2010
We present a patient with thalassemia major who developed a gastric ulcer, probably related to the use of deferasirox. Although gastric ulcer is mentioned as infrequent adverse event in the scientific product information of deferasirox, in our current ...
De Moerloose, Barbara, Mondelaers, Veerle, HUNNINCK, KATHLEEN, Robays, Hugo, Bauters, Tieneke   +4 more
core   +1 more source

Ferritin level changes and erythroid improvement in a group of adult politransfused patients treated with Deferasirox

, 2018
Background and aims. Chelating agents therapy is recommended for polytransfused patients that have evidence of iron overload (an elevated serum ferritin or received over 20 units of red blood cell transfusions).
Iulia Andrea Zsoldos, Mihaela Iancu, Laura Urian, Anca Bojan, Tunde Torok, Andrada Viorica Parvu   +5 more
core   +1 more source

Renal function in β-thalassemia major receiving desferal versus deferasirox [PDF]

, 2018
Introduction: Deferasirox is a new oral iron chelating agent which has been administered in β-thalassemia major patients in last few years. There is some reports regarding nephrotoxicity of this agent; however, no comparative study has been conducted ...
Azarkeivan, A., Sabzghabaei, F., Darnahal, M.   +2 more
core  

Deferasirox Removes Cardiac Iron and Attenuates Oxidative Stress in the Iron-overloaded Gerbil

, 2009
Iron-induced cardiovascular disease is the leading cause of death in iron-overloaded patients. Deferasirox is a novel, once daily oral iron chelator that was recently approved for the treatment of transfusional iron overload. Here, we investigate whether
Al-Rousan, Rabaa M., Blough, Eric R., Paturi, Satyanarayana, Kakarla, Sunil K., Walker, Ernest M., Gutta, Anil K., Laurino, Joseph P.   +6 more
core   +1 more source

Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation

Scientific Reports
Menopause is a natural biological aging process characterized by the loss of ovarian follicular function and decrease estrogen levels. These hormonal fluctuations are associated with increased iron levels, which ultimately lead to iron accumulation. This
Niloofar Honari, Mahtab Sayadi, Seyed Mehdi Sajjadi, Somayeh Solhjoo, Gholamreza Anani Sarab   +4 more
doaj   +1 more source

Fluvastatin suppresses hemin-induced cell death, reactive oxygen species generation, and elevated labile iron pool

Hematology, Transfusion and Cell Therapy
Background: In transfusion-related iron overload, macrophage/reticuloendothelial cells are the first site of haem-derived iron accumulation. The prevention of haem-induced cytotoxicity in macrophages may represent a target for iron overload treatment ...
Shion Imoto, Katsuyasu Saigo, Mari Kono, Ayako Ohbuchi, Tohru Sawamura, Yuji Mizokoshi, Takashi Suzuki   +6 more
doaj   +1 more source

Brazilian bulletin for health technology assessment: deferasirox for iron overload [PDF]

, 2011
Objetivo: Avaliar a evidência de eficácia e segurança do deferasirox para o tratamento da sobrecarga de ferro relacionada à betatalassemia, doença falciforme e síndrome mielodisplásica, em comparação a outros quelantes de ferro disponíveis no Brasil ...
Silva, Marcus Tolentino [UNIFESP]
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Pharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and its Iron Complex in Rats

, 2008
Deferasirox (Exjade®, ICL670, CGP72670) is an iron-chelating drug for oral treatment of transfusional iron-overload in patients suffering from β-thalassemia or sickle cell disease. The pharmacokinetics and disposition of deferasirox were investigated in
T. Faller, Waldmeier, Felix, G. J. M. Bruin, Boernsen, K. Olaf, F. Waldmeier, Nick, Hanspeter, Faller, Thomas, H. Wiegand, A. Schweitzer, Wiegand, Hansjoerg, Schweitzer, Alain, Bruin, Gerardus, K.-O. Boernsen, J. Schneider, H. Nick, Schneider, Josef   +15 more
core   +1 more source

Successful Deferasirox Rechallenge and Treating Through Reaction in a Patient with Challenge-Proven Mild Immediate Reaction: A Case Report

Journal of Asthma and Allergy, 2020
Mongkhon Sompornrattanaphan,1 Thanachit Krikeerati,1,2 Chamard Wongsa,1 Torpong Thongngarm,1 Kittika Yampayon3 1Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok ...
Sompornrattanaphan M, Krikeerati T, Wongsa C, Thongngarm T, Yampayon K   +4 more
doaj  

Activity of Deferasirox in Mucorales: Influences of Species and Exogenous Iron

, 2011
Differences in deferasirox susceptibility among members of the order Mucorales are unknown. Here we show that Cunninghamella bertholletiae (four isolates) and Mucor species (five isolates) display higher deferasirox MICs and minimal fungicidal ...
Albert, Nathaniel, Lewis, Russell E., LEWIS, RUSSEL EDWARD, G. N. Pongas, Walsh, Thomas J., Nathaniel Albert, Pongas, Georgios N., Russell E. Lewis, R. Ben Ami, Thomas J. Walsh, N. Albert, T. J. Walsh, Georgios N. Pongas, Ben-Ami, Ronen, Ronen Ben-Ami, Kontoyiannis, Dimitrios P., Dimitrios P. Kontoyiannis, D. P. Kontoyiannis   +17 more
core   +1 more source