Results 41 to 50 of about 10,843 (242)

Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias: a randomized, open-label noninferiority study

Blood Advances, 2021
Key Points The efficacy of deferiprone was noninferior to deferoxamine for treating transfusional iron overload in patients with SCD or other anemias. The safety profile of deferiprone in patients with SCD was tolerable and similar to previous reports in
J. Kwiatkowski, Mona Hamdy, Amal El Beshlawy, F. Ebeid, Mohammed Badr, Abdulrahman Ali M AlShehri, J. Kanter, B. Inusa, Amira Adly, S. Williams, Yurdanur Kilinc, David Lee, F. Tricta, MS Elalfy   +13 more
semanticscholar   +1 more source

Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone

International Journal of Molecular Sciences, 2020
Ascorbic acid (AscH2) is one of the most important vitamins found in the human diet, with many biological functions including antioxidant, chelating, and coenzyme activities. Ascorbic acid is also widely used in medical practice especially for increasing
V. A. Timoshnikov, T. Kobzeva, N. Polyakov, G. Kontoghiorghes   +3 more
semanticscholar   +1 more source

Efficacy of the iron‐chelating agent, deferiprone, in patients with Parkinson's disease: A systematic review and meta‐analysis

CNS Neuroscience & Therapeutics
Several studies have reported iron accumulation in the basal ganglia to be associated with the development of Parkinson's Disease (PD). Recently, a few trials have examined the efficacy of using the iron‐chelating agent Deferiprone (DFP) for patients ...
Ahmed Negida, Nafisa M Hassan, Heba Aboeldahab, Youmna E Zain, Yasmin Negida, Shirin Cadri, Nivin Cadri, Leslie J. Cloud, Matthew J. Barrett, Brian D Berman   +9 more
semanticscholar   +1 more source

Treatment Response of Deferiprone in Infratentorial Superficial Siderosis: a Systematic Review

Cerebellum, 2021
Superficial siderosis describes haemosiderin deposition on the surface of the brain. When present on infratentorial structures, it can cause ataxia, sensorineural hearing loss and pyramidal signs. There is no proven treatment and patients experience slow
Andreas Flores Martin, P. Shanmugarajah, N. Hoggard, M. Hadjivassiliou   +3 more
semanticscholar   +1 more source

Deferiprone and idiosyncrasic neutropenia: light and shadow. [PDF]

Blood Adv
Fioredda F, Forni GL.
europepmc   +3 more sources

Efficacy and safety of deferoxamine, deferasirox and deferiprone triple iron chelator combination therapy for transfusion-dependent β-thalassaemia with very high iron overload: a protocol for randomised controlled clinical trial

BMJ Open
Introduction Despite the improvement in medical management, many patients with transfusion-dependent β-thalassaemia die prematurely due to transfusion-related iron overload.
A. Premawardhena, Chamodi Perera, Muditha Nayana Wijethilaka, S. Wanasinghe, R. Rajakaruna, R. Samarasinghe, Senani Williams, S. Mettananda   +7 more
semanticscholar   +1 more source

SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia

British Journal of Haematology, 2021
Beta‐thalassaemia is an inherited blood disorder characterised by ineffective erythropoiesis and anaemia. Consequently, hepcidin expression is reduced resulting in increased iron absorption and primary iron overload.
J. Vadolas, Garrett Z Ng, K. Kysenius, P. Crouch, S. Dames, M. Eisermann, T. Nualkaew, S. Vilcassim, U. Schaeper, G. Grigoriadis   +9 more
semanticscholar   +1 more source

Agranulocytosis with deferiprone treatment of superficial siderosis [PDF]

BMJ Case Reports, 2013
Superficial siderosis of the central nervous system is a rare neurological disorder caused by deposits of haemosiderin on subplial brain matter. Characterised by a thin dark layer surrounding the brain stem, cerebellum and cortical fissures on the T2-weighted MRI, symptoms include sensorineural hearing loss and progressive gait ataxia.
Marisa Gossweiler, Maureen Callaghan, Nikhil Anand Huprikar, Paul Bunge   +3 more
openaire   +3 more sources

Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles

Advanced Science, EarlyView.
A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi, Liuyu Zhu, Guosheng Hu, Liling Zheng, Songying Ouyang   +13 more
wiley   +1 more source

Comparative efficacy of deferiprone, deferoxamine and combination of deferiprone and deferoxamine on serum ferritin value in Beta-Thalassemia patients [PDF]

, 2015
Background: Iron overload is a predictable and life-threatening complication in patients with thalassemia. Effective and convenient iron chelation remains one of the main targets of clinical management of thalassemia major.
Amlashi, H.M., Behnampour, N., Jahazi, A., Mirbehbahani, N.   +3 more
core   +1 more source