Results 41 to 50 of about 5,411 (177)

Overexpression of Transferrin Receptor in Esophageal Squamous Cell Cancer Suggests Poor Prognosis and Potential Therapy

Cancer Science, Volume 117, Issue 2, Page 393-406, February 2026.
This study aimed to evaluate transferrin receptor (TfR) expression in human esophageal squamous cell cancer (ESCC) specimens and investigate the correlation between TfR overexpression and clinicopathological characteristics. Furthermore, we explored the potential of targeting iron metabolism pathways as a novel therapeutic strategy for ESCC.
Naoki Ikenaga, Tsuyoshi Takahashi, Koji Tanaka, Satoshi Serada, Minoru Fujimoto, Kota Momose, Kotaro Yamashita, Tomoki Makino, Takuro Saito, Kazuyoshi Yamamoto, Yukinori Kurokawa, Kiyokazu Nakajima, Tomomi Fujii, Eiichi Morii, Tetsuji Naka, Hidetoshi Eguchi, Yuichiro Doki   +16 more
wiley   +1 more source

Deferiprone [PDF]

Reactions Weekly, 2020
  +6 more sources

Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis. [PDF]

PLoS ONE, 2015
Nephrogenic systemic fibrosis is associated with gadolinium contrast exposure in patients with reduced kidney function and carries high morbidity and mortality.
Chhanda Bose, Judit K Megyesi, Sudhir V Shah, Kim M Hiatt, Kimberly A Hall, Oleg Karaduta, Sundararaman Swaminathan   +6 more
doaj   +1 more source

Research Progress of Ferroptosis in Cerebral Infarction

Brain and Behavior, Volume 16, Issue 1, January 2026.
Cerebral infarction triggers ischemia–reperfusion injury, leading to iron overload, oxidative stress, and mitochondrial dysfunction, which together initiate ferroptosis—an iron‐dependent, lipid peroxidation–driven form of neuronal death. Disruption of the System Xc−/GSH/GPX4 antioxidant axis and ACSL4‐mediated PUFA phospholipid enrichment accelerates ...
Yilan Fei, Qi Leng
wiley   +1 more source

Chelation Therapy for Rare Earth Element Toxicity: Current Evidence, Challenges and Future Directions

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT The accelerating integration of rare earth elements (REEs) in advanced technologies has generated rising concern over human exposure and the attendant toxicological risks. This review presents an up‐to‐date synthesis of current evidence on REE toxicity across multiple exposure pathways, including inhalation, ingestion and occupational contact,
Jose L. Domingo
wiley   +1 more source

Timed non-transferrin bound iron determinations probe the origin of chelatable iron pools during deferiprone regimens and predict chelation response

Haematologica, 2012
Background Plasma non-transferrin bound iron refers to heterogeneous plasma iron species, not bound to transferrin, which appear in conditions of iron overload and ineffective erythropoiesis.
Yesim Aydinok, Patricia Evans, Chantal Y. Manz, John B. Porter   +3 more
doaj   +1 more source

Iron‐related intercellular communication in the liver: Main players and mechanisms

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Iron exchange between liver cell types is vital for organism health, yet its mechanisms remain poorly understood. In this review, we address intercellular communication governing hepatic iron regulation across different liver diseases. We summarize recent insights into how hepatocytes, macrophages, endothelial and stellate cells coordinate iron storage,
Óscar Fonseca, Paulo J. Oliveira, Martina U. Muckenthaler, Ana C. Moreira, M. Salomé Gomes   +4 more
wiley   +1 more source

Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload

Journal of Cardiovascular Magnetic Resonance, 2011
Background Thalassaemia major (TM) patients need regular blood transfusions that lead to accumulation of iron and death from heart failure. Deferiprone has been reported to be superior to deferoxamine for the removal of cardiac iron and improvement in ...
Gotsis Efstathios D, Aessopos Athanassios, Piga Antonio, Ladis Vasili, Karagiorga Markissia, Berdoukas Vasili, Alam Mohammed H, Carpenter John, Alpendurada Francisco, Smith Gillian C, Tanner Mark A, Westwood Mark A, Galanello Renzo, Roughton Michael, Pennell Dudley J   +14 more
doaj   +1 more source

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, Volume 12, Issue 47, December 18, 2025.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Follow‐Up of 3‐Year Luspatercept Treatment in a Transfused ß‐Thalassemia Patient. Bone Marrow: An Undervalued Iron Store

eJHaem, Volume 6, Issue 6, December 2025.
ABSTRACT Introduction Treatment with luspatercept may improve transfusion requirements in transfusion‐dependent thalassemia (TDT), but the improved erythroid maturation in the bone marrow influences body iron distribution. Case Report We report on sequential organ iron measurements in a TDT patient under luspatercept treatment.
Matthias Bleeke, Claudia Niekrens, Soumya Datta, Regine Grosse, Filomena Longo, Isabel Molwitz, Roland Fischer   +6 more
wiley   +1 more source