Results 71 to 80 of about 10,843 (242)

Inhibition of prostate cancer proliferation by Deferiprone

NMR in Biomedicine, 2017
Cancer growth and proliferation rely on intracellular iron availability. We studied the effects of Deferiprone (DFP), a chelator of intracellular iron, on three prostate cancer cell lines: murine, metastatic TRAMP‐C2; murine, non‐metastatic Myc‐CaP; and human, non‐metastatic 22rv1.
Rui V. Simões, Suresh Veeraperumal, Inna S. Serganova, Natalia Kruchevsky, Joseph Varshavsky, Ronald G. Blasberg, Ellen Ackerstaff, Jason A. Koutcher   +7 more
openaire   +4 more sources

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

MedComm, Volume 6, Issue 7, July 2025.
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu, Jiachen Liu, Yinhuai Wang, Fei Deng, Zebin Deng   +4 more
wiley   +1 more source

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

Movement Disorders, Volume 40, Issue 7, Page 1307-1317, July 2025.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles, Dilan Athauda, Thomas R. Barber, Roger A. Barker, David T. Dexter, Susan Duty, Romy Ellis‐Doyle, Sonia Gandhi, Joel Handley, Edwin Jabbari, Keith Martin, Kevin McFarthing, Georgia Mills, Heather Mortiboys, Stephen Mullin, Rebecca Petty, Esther Sammler, Paula Scurfield, Simon R.W. Stott, George K. Tofaris, Li Wei, Caroline H. Williams‐Gray, Alan Wong, Marie‐Louise Zeissler, Richard K. Wyse, Camille B. Carroll, Thomas Foltynie, Oliver Bandmann, Anthony H.V. Schapira, on behalf of the EJS ACT‐PD Consortium, Thomas Foltynie, Camille B Carroll, Roger Barker, James Carpenter, Yoav Ben‐Shlomo, Mark Edwards, Alan Whone, Carl Counsell, Caroline S Clarke, Matthew Burnell, Kate Hockey, Anna Jewell, Priti Gros, Tom Barber, Anette Schrag, Rimona S Weil, Caroline H Williams‐Gray, Michele T Hu, Lynn Rochester, Paola Piccini, Henrik Zetterberg, Alastair Noyce, Michael Lawton, Ashwani Jha, Brook Huxford, Shlomi Haar Millo, K. Ray Chaudhuri, Carroll Siu, Michèle Bartlett, Kuhan Pushparatnam, Daniel van Wamelen, Anthony HV Schapira, Oliver Bandmann, Simon Stott, George Tofaris, Esther Sammler, Heather Mortiboys, Li Wei, Alan Wong, Susan Duty, David Dexter, Edwin Jabbari, Stephen Mullin, Huw Morris, David Breen, Christian Lambert, Prasad Korlipara, Monty Silverdale, Kailash Bhatia, Alison Yarnall, Raj Khengar, Helen Collins, Fleur Hudson, Rebecca Croucher, Sandra Bartolomeu‐Pires, Veena Agarwal, Jennifer Allison, Jodie Forbes, Alex Edwards, Sheila Wonnacott, Dilan Athauda, Joy Duffen, Sonia Gandhi, Emily Henderson, Jen Black, Karen Matthews, Vince Greaves, Eric Deeson, Laurel Miller, Joel Handley, Helen Matthews, Kevin McFarthing, Amit Batla, Nikul Bakshi, Miriam Parry, Natasha Ratcliffe, Cheney Drew, Naveena Kapur, Anaya Navangul, Shafaq Ali, Katherine Fletcher, Claire Bale, Cristina Gonzalez‐Robles, Marie‐Louise Zeissler, Georgia Mills, Romy Ellis‐Doyle, Sally Collins, Rebecca Petty   +117 more
wiley   +1 more source

Unravelling the genome-wide contributions of specific 2-alkyl-4-quinolones and PqsE to quorum sensing in Pseudomonas aeruginosa [PDF]

, 2016
The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal target for the development of anti-virulence agents.
A Bergh, A Ilangovan, AT Nguyen, B Folch, CA Knoten, CA Ortori, CE Dulcey, DA Recinos, DS Wade, E Déziel, E Déziel, Emanuela Frangipani, Everett Pesci, F Bredenbruch, F Imperi, F Lépine, G Rampioni, G Rampioni, G Singh, G Xiao, Giordano Rampioni, GL Winsor, HL Barr, I Stojiljkovic, IA Macdonald, J Lee, JD Storey, Jean-Frédéric Dubern, JF Dubern, JM Farrow 3rd, JP Coleman, JR Boelaert, JW Schertzer, L Mashburn-Warren, L Voggu, LA Gallagher, LE Dietrich, Livia Leoni, M Hogardt, M Palma, M Toyofuku, Marilena Falcone, Matthew P. Fletcher, ME El Zowalaty, MG Thompson, Miguel Cámara, MJ Kirisits, P Visca, P Williams, Paolo Visca, Paul Williams, R Hazan, S Aendekerk, S Chugani, S Heeb, S Häussler, S Yu, SL Drees, SL Drees, SL Gellatly, SP Diggle, Stephan Heeb, UA Ochsner, Y Liu, YM Zhang   +64 more
core   +4 more sources

Emerging Links Between Ferroptosis and Neurodegeneration: Implications for Disease Mechanisms and Nutraceutical Interventions

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
Ferroptosis, a controlled cell death, is driven by iron and characterized by reactive oxygen species and lipid peroxidation. The impact of lipid peroxides, GSH/GPX4, and iron metabolism–targeting small molecule inhibitors is discussed. Nucleic acids, proteins, and phytochemicals are implicated as inhibitors of ferroptosis.
Anwar Ali, Quratulain Babar, Ayesha Saeed, Domenico Sergi, Nenad Naumovski, Isam A. Mohamed Ahmed, Ghalia Shamlan, Halah Abdulrahman Hafiz, Muhammad Faisal Manzoor, Joanna Trafialek, Felix Kwashie Madilo   +10 more
wiley   +1 more source

Serial echocardiographic left ventricular ejection fraction measurements: a tool for detecting thalassemia major patients at risk of cardiac death [PDF]

, 2013
Cardiac damage remains a major cause of mortality among patients with thalassemia major. The detection of a lower cardiac magnetic resonance T2* (CMR-T2*) signal has been suggested as a powerful predictor of the subsequent development of heart failure ...
Angastiniotis, M, Barone, R, Calvaruso, G, Campisi, S, Capra, M, Caruso, V, Chattipakorn, N., Cianciulli, P, Cuccia, L, Elefteriou, A, Filosa, A, Gerardi, C, Hamzac, H, Maggio, A, Mancuso, L, Phrommintikul, A, Pitrolo, L, Prossomariti, L, Rigano, P, Telfer, P, VITRANO, Angela, Walkerc, JM   +21 more
core   +1 more source

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

Scientific Reports, 2017
Parkinson’s disease (PD) is associated with increased iron levels in the substantia nigra (SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to chelate iron from various brain regions and improve PD symptomology ...
A. Martín-Bastida, R. Ward, R. Newbould, P. Piccini, D. Sharp, Christina Kabba, Maneesh C. Patel, M. Spino, J. Connelly, F. Tricta, R. Crichton, D. Dexter   +11 more
semanticscholar   +1 more source

Comparative study of Deferiprone versus Deferiprone with Deferasirox as iron chelation therapy in Thalassemic children

Bangladesh Journal of Child Health, 2020
Background: Combination therapy of Deferiprone (DFP) with Deferasirox (DFX) is an efficacious and safe modality to reduce serum ferritin in multi-transfused children with thalassemia. Objectives: To compare the efficacy of Deferiprone versus Deferiprone with Deferasirox as iron chelation therapy of transfusion dependent thalassemia children.
Sayeeda Anwar, Kabirul Islam, Syeda Jarka Jahir, Akm Amirul Morshed, Afiqul Islam   +4 more
openaire   +2 more sources

The FDA Has Ended Required Blood Monitoring for Clozapine Use—Will This Impact the Management of Parkinson's Disease Psychosis?

Movement Disorders, EarlyView.
Daniel Weintraub, Izabelle Schoen
wiley   +1 more source

The History of Deferiprone (L1) and the Paradigm of the Complete Treatment of Iron Overload in Thalassaemia

Mediterranean Journal of Hematology and Infectious Diseases, 2020
Deferiprone (L1) was originally designed, synthesised and screened in vitro and in vivo in 1981 by Kontoghiorghes G. J. following his discovery of the novel alpha-ketohydroxypyridine class of iron chelators (1978–1981), which were intended for clinical ...
G. Kontoghiorghes, Marios Kleanthous, C. Kontoghiorghe   +2 more
semanticscholar   +1 more source