Results 81 to 90 of about 6,396 (177)

Proteinuria and chelator-associated renal dysfunction in β-thalassemia major: insights from a single-center clinical study [PDF]

Pharmacia
Introduction: Transfusion-dependent β-thalassemia major (β-TM) is increasingly complicated by renal injury related to iron overload and chelation. This study aimed to evaluate albuminuria/proteinuria in β-TM and their association with chelation regimen.
Liliya Stoyanova, Miroslava Benkova-Petrova, Aleksandar Petrov, Pavel Abushev, Simeon Marinov, Martina Stoeva, Yavor Petrov   +6 more
doaj   +3 more sources

The Evaiuation of chalator therapy in reducing serum ferritin and improving Ejection fraction (EF%) in thalassemic patients

Iranian South Medical Journal, 2015
Background: Thalassemic syndroms are the most common genetic disease in the world that related to blood transfusion and iron overload in the body. Cardiac complications are the leading cause of death in patients with thalassemia.
Saeadh Firouzbakhtkh, Khadejeh Ghasemi, Nilofar Motamed, Mahmoodreza Sarrikhani   +3 more
doaj  

Deferiprone in Friedreich ataxia: A 6-Month randomized controlled trial.

, 2014
We conducted a 6-month, randomized, double-blind, placebo-controlled study to assess safety, tolerability, and efficacy of deferiprone in Friedreich ataxia (FRDA).JOURNAL ARTICLESCOPUS: ar.jSCOPUS: ar.jFLWINinfo:eu-repo/semantics ...
Pandolfo, Massimo, Mark A. Tarnopolsky, Mariotti, Caterina, Geneieve Tai, Fernando Tricta, Sanz-Gallego, Irene, Michael Spino, Spino, Michael, Franco Taroni, Taroni, Franco, Delatycki, Martin B, Caterina Mariotti, Le Quan Sang, Kim Hanh, Kim Hanh Le Quan Sang, Tai, Geneieve, Tricta, Fernando, Irene Sanz‐Gallego, Munnich, Arnold, Arnold Munnich, Tarnopolsky, Mark A, Javier Arpa, Massimo Pandolfo, Arpa, Javier, Martin B. Delatycki   +23 more
core   +1 more source

Prevention of Iron Overload and Long Term Maintenance of Normal Iron Stores in Thalassaemia Major Patients using Deferiprone or Deferiprone Deferoxamine Combination

, 2017
Decrease in mortality and morbidity is observed in thalassaemia major patients with reduced iron load in comparison to heavy iron loaded patients. Effective and complete treatment of transfusional iron overload can be achieved by chelation protocols that
Christina Kontoghiorghe, Annita Kolnagou, George Kontoghiorghes   +2 more
core   +1 more source

Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes

Drug Design, Development and Therapy, 2016
Christina N Kontoghiorghe, George J Kontoghiorghes Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus Abstract: The prevalence rate of thalassemia, which is endemic in Southeast Asia, the Middle East, and
Kontoghiorghe CN, Kontoghiorghes GJ
doaj  

Datasheet1_Chitogel with deferiprone following endoscopic sinus surgery: improved wound healing and microbiome.pdf

BackgroundAdhesion formation, sinus ostial narrowing, and presence of pathogenic bacteria are associated with poor outcomes following endoscopic sinus surgery (ESS) for chronic rhinosinusitis.
Erich Vyskocil (4739916), Anna Megow (18300424), Yazeed Alsuliman (18300427), Clare Cooksley (4169461), George Bouras (835677), William Murphy (308098), Sarah Vreugde (541061), Peter-John Wormald (541063)   +7 more
core   +1 more source

Sex and Gender Differences in Iron Chelation

Biomedicines
Background/Objectives: In the absence of physiological mechanisms to excrete excessive iron, the administration of iron chelation therapy is necessary.
Sarah Allegra, Stefano Comità, Antonella Roetto, Silvia De Francia   +3 more
doaj   +1 more source

Effect of deferiprone in HIV-infected primary cells: Apoptotic DNA fragmentation, deoxyhypusyl-eIF5A accumulation, and DOHH activity.

, 2016
Apoptotic DNA fragmentation (Panel A) was detected by terminal deoxynucleotide transferase dUTP nick end labeling (TUNEL) of single-donor peripheral blood mononuclear cells, maintained in short-term non-replenished cultures as described [43].
Myung Hee Park (176990), Bernadette M. Cracchiolo (462186), Paul E. Palumbo (462178), Michael Spino (462182), John Connelly (462188), Bart Holland (462191), Tsafi Pe’ery (462192), Axel-Rainer Hanauske (462179), Jonathan Karn (220557), Hartmut M. Hanauske-Abel (462176), Deepti Saxena (462177), Michael B. Mathews (35045), Fernando Tricta (462187), Darlene D’Alliessi Gandolfi (2793712)   +13 more
core   +1 more source

Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major

, 2006
Deferoxamine (DFO) therapy has been associated with improved survival of thalassemia patients. However, cardiac disease remains the main cause of death in those patients. In 1995, the oral chelator deferiprone became available for clinical use.
M. A. Romeo, M. D. Cappellini, C. Borgna Pignatti, G. L. Forni, P. De Stefano, BORGNA, Caterina, G. C. Del Vecchio, R. Ghilardi, M. R. Gamberini, A. Cnaan, M.D. Cappellini, A. Piga, H. Zhao   +12 more
core   +1 more source

The Oxidative Stress Response Highly Depends on Glucose and Iron Availability in Aspergillus fumigatus

Journal of Fungi
Pathogens have to cope with oxidative, iron- and carbon(glucose)-limitation stresses in the human body. To understand how combined iron–carbon limitation alters oxidative stress responses, Aspergillus fumigatus was cultured in glucose–peptone or peptone ...
Tamás Emri, Károly Antal, Kinga Varga, Barnabás Csaba Gila, István Pócsi   +4 more
doaj   +1 more source