Results 81 to 90 of about 10,843 (242)

Acute splenomegaly, haemolysis, and thrombocytopenia following luspatercept initiation in a patient with transfusion‐dependent thalassaemia: A case report

British Journal of Haematology, Volume 206, Issue 6, Page 1806-1810, June 2025.
Summary Patients with transfusion‐dependent thalassaemia (TDT) require chronic, life‐sustaining red blood cell transfusions, which contribute to iron overload and associated morbidity and mortality. Luspatercept, an inhibitor of the transforming growth factor‐beta pathway, decreases transfusion requirements in a subset of transfusion‐dependent β ...
Bianca Zaidel, Stephanie Garland, Hayley Merkeley   +2 more
wiley   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, Volume 45, Issue 3, Page 177-201, June 2025.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Deferiprone and gallium-protoporphyrin have the capacity to potentiate the activity of antibiotics in Staphylococcus aureus small colony variants [PDF]

, 2017
Small colony variants (SCVs) of bacteria like Staphylococcus aureus are characterized by a reduced colony size and are linked to increased antibiotic tolerance and resistance.
Clive A. Prestidge, Clive A. Prestidge, Guimin Zhang, Katharina Richter, Nicky Thomas, Nicky Thomas, Peter-John Wormald, Sarah Vreugde, Tom Coenye   +8 more
core   +3 more sources

Tumoroid Model Reveals Synergistic Impairment of Metabolism by Iron Chelators and Temozolomide in Chemo‐Resistant Patient‐derived Glioblastoma Cells

Advanced Science, Volume 12, Issue 20, May 29, 2025.
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick B. Walter, Mohsen Akbari   +8 more
wiley   +1 more source

Effects of chelators (desferal, deferiprone & deferaairox) on the growth of klebsiella and aeromonas isolated from transfusion dependent thalassemia patients [PDF]

, 2010
Poster Presentation (Doctor’s Session)Infection is among the leading causes of death for thalassemia major patients. The known predisposing factors of infection include prior splenectomy, iron overload and use of iron chelator such as desferal ...
Chan, GCF, Chan, S, Ha, SY, Ho, PL
core  

Deferoxamine retinopathy: spectral domain-optical coherence tomography findings [PDF]

, 2014
BACKGROUND: To describe the spectral domain optical coherence tomography (SD-OCT) findings of a patient who developed pigmentary retinopathy following high-dose deferoxamine administration.
Chao-Ping Yang, Cheng-Hsiu Wu, Chi-Chun Lai, Wei-Chi Wu, Yi-Hsing Chen   +4 more
core   +1 more source

Induction of Cell Death by Combined Treatment with Photosensitizer‐Chitosan Nanoparticles and the Ferroptosis Inducer RSL3 in Breast Cancer Cell Lines

Advanced NanoBiomed Research, Volume 5, Issue 5, May 2025.
This study demonstrates that combination of phosphosensitizer‐conjugated chitosan nanoparticles and ferroptosis inducer RSL3 increases cell death in mesenchymal breast cancer cells. Data suggests that this is attributed to variations in ferroptosis‐related protein expression, lipid peroxydation and mitochondrial function.
Marek Feith, Saikat Das Sajib, Anne Grethe Myrann, Anders Høgset, Pablo Garrido, Alfredo Martinez, Erik Knutsen, Kirsten Sandvig, Tore Skotland, Gunhild Mari Mælandsmo, Tore‐Geir Iversen   +10 more
wiley   +1 more source

Effect of trace iron levels and iron withdrawal by chelation on the growth of Candida albicans and Candida vini [PDF]

, 2017
The iron requirements of the opportunistic pathogenic yeast, Candida albicans, and the related nonpathogenic spoilage yeast Candida vini were investigated along with their responses to various exogenous iron chelators.
Holbein, Bruce E., Mira de Orduña, Ramón   +1 more
core  

Nickel hydroxide films in contact with an electroactive solution. A study employing electrochemical impedance measurements [PDF]

, 2016
The deactivation of nickel hydroxide films after prolonged storage times without use was studied. This study was carried out in the context of the Rotating Disc Electrode Voltammetry (RDEV) andElectrochemical Impedance Spectroscopy (EIS) when the nickel ...
Tucceri, Ismael Ricardo
core   +2 more sources

Transferrin Receptor Promotes Endometrial Cancer Proliferation by Activating the Iron‐Dependent PI3K/AKT/mTOR Signaling Pathway

Cancer Science, Volume 116, Issue 5, Page 1352-1365, May 2025.
TFRC may serve as a critical prognostic indicator for risk assessment in EC patients and propose TFRC as a promising therapeutic target to impede EC progression. The upregulation of TFRC‐mediated iron absorption facilitated the proliferation of EC, suggesting that iron chelators had the potential to be a promising therapeutic agent for the treatment of
Yufei Yang, Ying Ning, Yu Chen, Tian Tian, Xinyan Gao, Yan Kong, Ke Lei, Zhumei Cui   +7 more
wiley   +1 more source