Results 71 to 80 of about 32,113 (291)
Archives of Pharmaceutical Sciences Ain Shams University, 2020 Cisplatin is a major classical anticancer agents. However, cisplatin induced nephrotoxicity remains a major dose limiting side effect. Several studies has highlighted the role of catalytic iron content in several diseases including cispatin ...
Mohamed M Elmazar +5 more
doaj +1 more source
A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery [PDF]
, 2008 Background: Several human pathologies, including neoplasia and ischemic cardiovascular diseases, course with an unbalance between oxygen supply and demand ( hypoxia).
Alcaide-German, ML +4 more
core
Regulation of virulence in Francisella tularensis by small non-coding RNAs [PDF]
, 2011 Using a cDNA cloning and sequencing approach we have shown that Francisella tularensis expresses homologues of several small RNAs (sRNAs) that are well-conserved among diverse bacteria.
Alain Charbit +6 more
core +2 more sources
A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells
Advanced Science, EarlyView.An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet +5 more
wiley +1 more source
Influence of iron- and zinc-chelating agents on neutrophil extracellular trap formation
Central European Journal of Immunology, 2021 Release of neutrophil extracellular traps (NETs) is one of the neutrophils’ mechanisms involved in the response to infection. NETs are released from the cell in response to a biological or synthetic stimulus to entrap, immobilize and kill pathogens ...
Weronika Kuźmicka +5 more
doaj +1 more source
Secondary Hematoma Expansion and Perihemorrhagic Edema after Intracerebral Hemorrhage: From Bench Work to Practical Aspects. [PDF]
, 2017 Intracerebral hemorrhages (ICH) represent about 10-15% of all strokes per year in the United States alone. Key variables influencing the long-term outcome after ICH are hematoma size and growth.
Lim-Hing, Krista, Rincon, Fred
core +2 more sources
Advanced Science, EarlyView.Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu +11 more
wiley +1 more source
Дефероксамин как патогенетически обоснованный препарат комплексной терапии пациентов с острым панкреатитом [PDF]
, 2009 ПАНКРЕАТИТ ОСТРЫЙ НЕКРОТИЗИРУЮЩИЙфлегмон забрюшинного пространстваЗАБРЮШИННОЕ ПРОСТРАНСТВОдефероксаминобмен железаЖЕЛЕЗА ОБМЕНА НАРУШЕНИЯФЛЕГМОНАСМЕРТЕЛЬНЫЙ ИСХОДЛЕТАЛЬНЫЙ ИСХОДМУЛЬТИОРГАННАЯ НЕДОСТАТОЧНОСТЬПОЛИОРГАННОЙ НЕДОСТАТОЧНОСТИ СИНДРОМсиндром ...
Глущенко, А. В. +4 more
core +2 more sources
Disease modifying therapy for multiple system atrophy – Parkinsonian Type [PDF]
, 2017 BACKGROUND: Multiple System Atrophy –Parkinsonian Type (MSA-P) is a rare, rapidly progressive neurodegenerative disease without any current treatment.
Dwyer, Sean Sullivan
core
ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling
Advanced Science, EarlyView.ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao +19 more
wiley +1 more source