Results 71 to 80 of about 14,894 (236)
Development of Deferoxamine‐Functionalized Cyclodextrin Polymer for Targeted Iron Chelation
ChemistryOpen, EarlyView.The cyclodextrin polymer is conjugated with 35 deferoxamine units and can form iron(III) complexes. The polymer exhibits significantly lower antiproliferative activity than free deferoxamine. The cyclodextrin polymer with multiple deferoxamine units may present a promising strategy for improving the efficacy of iron chelation therapies.
Roberta Panebianco +2 more
wiley +1 more source
Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy
Smart Molecules, EarlyView.Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan +4 more
wiley +1 more source
Aging Cell, EarlyView.Superoxide activates ferroptosis through the Haber‐Weiss reaction and contributes to the development of age‐related macular degeneration. MnSOD‐depleted RPE cells are susceptible to blue light‐induced ferroptosis. MnSOD deficiency promotes Hsp70‐driven ubiquitin‐mediated degradation of GPX4.
Ying Huang +10 more
wiley +1 more source
The role of iron in normal and impaired testicular function
Andrology, EarlyView.Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer +2 more
wiley +1 more source
The FEBS Journal, EarlyView.Recent studies emphasize alternative functions of FTH1 relevant for nuclear processes, such as transcriptional regulation. This study shows a novel FTH1/BRD2 association in non‐small cell lung carcinoma (NSCLC). This nuclear interaction affects BRD2 protein stability in aggressive NSCLC cells.
Stefania Scicchitano +9 more
wiley +1 more source
Protective effects of combined superoxide dismutase and deferoxamine on recovery of cerebral blood flow and function after cardiac arrest in dogs. [PDF]
, 1987 Erga Cerchiari +3 more
openalex +1 more source
Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches
MedComm – Future Medicine, Volume 4, Issue 3, September 2025.Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia +4 more
wiley +1 more source
Mitochondria ATP Pro‐Ferroptosis by Adjusting the Conversion of PUFA to PUFA‐PLs
MedComm – Oncology, Volume 4, Issue 3, September 2025.Glutamine deprivation can promote PUFA oxidation and PTGS2 expression through the upregulation of intracellular ROS, but not ferroptosis. Because glutamine deficiency exhausts mitochondrial ATP, thereby hinders the conversion of PUFA into their active form of PUFA‐CoA needed for lipid synthesis.
Chaoyi Xia +3 more
wiley +1 more source
ChemSusChem, Volume 18, Issue 16, August 6, 2025.Deferiprone is synthesized under solvent‐free mechanochemical conditions using ball milling. Methylammonium chloride and KOH enable efficient substitution of the oxygen atom in the maltol scaffold with a methylamine moiety, avoiding the limitations of methylamine solutions.
Francesco Basoccu +6 more
wiley +1 more source
Deferoxamine enhances phagocytic function of human polymorphonuclear leukocytes [PDF]
, 1984 BS van Asbeck +4 more
openalex +1 more source