Results 51 to 60 of about 18,326 (214)
The Availability of Iron Is Involved in the Murine Experimental Toxoplasma gondii Infection Outcome
Microorganisms, 2020 Iron is an important constituent of our environment, being necessary for both mammalian and pathogenic protozoa survival. Iron-containing proteins exert a wide range of biological processes such as biodegradation and biosynthesis, as well as immune ...
Mário Cézar Oliveira +5 more
doaj +1 more source
BMC Ophthalmology, 2021 Background Deferoxamine retinopathy is the informally designated term used to describe a characteristic pattern of outer retinal degeneration in iron-overloaded chronic anemia patients who are treated with deferoxamine. We hypothesize that insufficiently
Mohamed Belmouhand +5 more
doaj +1 more source
PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling
Advanced Science, EarlyView.PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu +13 more
wiley +1 more source
In-vitro Apoptotic Effects of Deferoxamine on the Glioblastoma Cell Line
Iranian South Medical Journal, 2019 Background: Research suggests the inhibitory effects of deferoxamine as an iron chelator on erythroleukemia cells. The present study was conducted to investigate the effects of deferoxamine on B92 cells as a model of glial cells carcinoma.
Mahtab Pourkamalzadeh +1 more
doaj
A Novel Star Like Eight-Arm Polyethylene Glycol-Deferoxamine Conjugate for Iron Overload Therapy
Pharmaceutics, 2020 The traditional iron chelator deferoxamine (DFO) has been widely used in the treatment of iron overload disease. However, DFO has congenital disadvantages, including a very short circular time and non-negligible toxicity.
Bohong Yu +5 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui +12 more
wiley +1 more source
Archives of Pharmaceutical Sciences Ain Shams University, 2020 Cisplatin is a major classical anticancer agents. However, cisplatin induced nephrotoxicity remains a major dose limiting side effect. Several studies has highlighted the role of catalytic iron content in several diseases including cispatin ...
Mohamed M Elmazar +5 more
doaj +1 more source
Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality
BMEMat, EarlyView.Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim +9 more
wiley +1 more source
INHIBITION OF PROLIFERATION OF HUMAN-LEUKEMIC CELL-POPULATIONS BY DEFEROXAMINE
, 1986 Deferoxamine is a hydroxylamine which binds ferric ions to form a highly stable complex. Since iron is thought to be required at a critical stage for cell proliferation, we investigated the effect of deferoxamine on the proliferative activity of human ...
L. VILLA +4 more
core +1 more source
Bone histologic response to deferoxamine in aluminum–related bone disease [PDF]
, 1987 Bone histologic response to deferoxamine in aluminum–related bone disease. We have examined the changes in bone histology in 28 uremic patients after long–term treatment with the aluminum chelator, deferoxamine.
Endres, David B. +7 more
core +1 more source