Results 51 to 60 of about 25,953 (267)

A Novel Star Like Eight-Arm Polyethylene Glycol-Deferoxamine Conjugate for Iron Overload Therapy

Pharmaceutics, 2020
The traditional iron chelator deferoxamine (DFO) has been widely used in the treatment of iron overload disease. However, DFO has congenital disadvantages, including a very short circular time and non-negligible toxicity.
Bohong Yu, Yinxian Yang, Qi Liu, Aiyan Zhan, Yang Yang, Hongzhuo Liu   +5 more
doaj   +1 more source

A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery [PDF]

, 2008
Background: Several human pathologies, including neoplasia and ischemic cardiovascular diseases, course with an unbalance between oxygen supply and demand ( hypoxia).
Alcaide-German, ML, Del Peso, L, Garcia-Fernandez, LF, Landazuri, MO, Vara-Vega, A   +4 more
core  

A Re-evaluation of Electron-Transfer Mechanisms in Microbial Electrochemistry: Shewanella Releases Iron that Mediates Extracellular Electron Transfer [PDF]

, 2016
Exoelectrogenic bacteria can couple their metabolism to extracellular electron acceptors, including macroscopic electrodes, and this has applications in energy production, bioremediation and biosensing.
Artyushkova, Baron, Breuer, Carmona-Martinez, Chourey, Clarke, Cornejo, Coursolle, Du, D′Souza, Emde, Firer-Sherwood, Firer-Sherwood, Golitsch, Hartshorne, Hau, Kotloski, Logan, Lower, Luo, Malvankar, Marsili, Meitl, Okamoto, Okamoto, Peng, Pirbadian, Rabaey, Roy, Roy, Shi, Singh, Stamou, Worrall   +33 more
core   +1 more source

Nanoclay‐Engineered Scaffolds for the Controlled Delivery of Biomolecules in Regenerative Medicine

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Regenerative medicine combines biomaterials, cells, scaffolds, and bioactive agents via modern technologies to aid in the reconstruction and repair of damaged tissues. Among these, nanoclay scaffolds have demonstrated unique advantages in facilitating the delivery of therapeutic agents.
Mehri Shadi, Saeed Vafaei‐Nezhad, Ahmad Gholamalizadeh Ahangar   +2 more
wiley   +1 more source

Unlocking the potential of deferoxamine: a systematic review on its efficacy and safety in alleviating myocardial ischemia-reperfusion injury in adult patients following cardiopulmonary bypass compared to standard care

Therapeutic Advances in Cardiovascular Disease
Background: Reperfusion injury, characterized by oxidative stress and inflammation, poses a significant challenge in cardiac surgery with cardiopulmonary bypass (CPB).
Aashish Lamichhane, Sadish Sharma, Bishwas Bastola, Bikesh Chhusyabaga, Nabin Shrestha, Prajwal Poudel   +5 more
doaj   +1 more source

The effect of daily intraperitoneal injection of Deferoxamine in an acute model of Cisplatin induced nephrotoxicity

Archives of Pharmaceutical Sciences Ain Shams University, 2020
Cisplatin is a major classical anticancer agents. However, cisplatin induced nephrotoxicity remains a major dose limiting side effect. Several studies has highlighted the role of catalytic iron content in several diseases including cispatin ...
Mohamed M Elmazar , Ebtehal El-Demerdash, Samar S Azab, Reem N Elnaga, Eman M Mantawy, Mai M Abdelmageed   +5 more
doaj   +1 more source

The role of neutrophil gelatinase-associated lipocalin and iron homeostasis in object recognition impairment in aged sepsis-survivor rats

Scientific Reports, 2022
Older adult patients with sepsis frequently experience cognitive impairment. The roles of brain neutrophil gelatinase-associated lipocalin (NGAL) and iron in older sepsis patients remain unknown.
Yoshikazu Nikaido, Yoko Midorikawa, Tomonori Furukawa, Shuji Shimoyama, Daiki Takekawa, Masato Kitayama, Shinya Ueno, Tetsuya Kushikata, Kazuyoshi Hirota   +8 more
doaj   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis

Molecules
Deferoxamine, an iron chelator used to treat diseases caused by excess iron, has had a Food and Drug Administration-approved status for many years. A large number of studies have confirmed that deferoxamine can reduce inflammatory response and promote ...
Haijun Shen, Yane Ma, Yi Qiao, Chun Zhang, Jialing Chen, Ran Zhang   +5 more
doaj   +1 more source

Regulation of virulence in Francisella tularensis by small non-coding RNAs [PDF]

, 2011
Using a cDNA cloning and sequencing approach we have shown that Francisella tularensis expresses homologues of several small RNAs (sRNAs) that are well-conserved among diverse bacteria.
Alain Charbit, Eric Frapy, Guillaume Postic, Iharilalao Dubail, Jonathan Livny, Karin L. Meibom, Marion Dupuis   +6 more
core   +2 more sources