Results 41 to 50 of about 16,909 (214)

Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats.

, 1994
Iron catalyzes the formation of damaging reactive species during cerebral reperfusion. Brain iron concentration is highest at birth, so the brain of the asphyxiated newborn may be at increased risk of iron-dependent injury.
C Bero, R L Roberts, C Palmer
core   +1 more source

Deferoxamine Preconditioning of Irradiated Tissue Improves Perfusion and Fat Graft Retention [PDF]

, 2018
BACKGROUND: Radiation therapy is a mainstay in the treatment of many malignancies, but collateral damage to surrounding tissue, with resultant hypovascularity, fibrosis, and atrophy, can be difficult to reconstruct. Fat grafting has been shown to improve
Dre Irizarry, Chung, Natalie, Irizarry, Dre, Dung Nguyen, Longaker, Michael T, Derrick C. Wan, Arash Momeni, Lee, Gordon K, Natalie Chung, Geoffrey C. Gurtner, Michael T. Longaker, Charles P. Blackshear, Nguyen, Dung, Flacco, John, John Flacco, Gordon K. Lee, Wan, Derrick C, Gurtner, Geoffrey C, Blackshear, Charles P, Momeni, Arash   +19 more
core   +1 more source

Management of Iron Overload in Infants and Toddlers With Diamond–Blackfan Anemia Syndrome: A French–Italian Study

American Journal of Hematology, EarlyView.
ABSTRACT Diamond–Blackfan Anemia Syndrome (DBAS) is a rare congenital anemia often requiring chronic red blood cell transfusions from infancy. Without appropriate chelation, iron overload develops early and may be severe; however, no data are available on chelation in patients under 3 years of age.
Francesca Torchio, Baptiste Lecalvez, Emanuela Garelli, Coralie Mallebranche, Adriana Carando, Marie‐Pierre Castex, Nathalie Garnier, Marco Zecca, Nathalie Aladjidi, Elisa Bertoni, Arthur Sterin, Maria Licciardello, Anne Sirvent, Antonella Sau, Isabelle Marie, Benedicte Bruno, Lydie M. Da Costa, Franca Fagioli, Paola Quarello, Thierry Leblanc   +19 more
wiley   +1 more source

Aluminum removal by peritoneal dialysis: Intravenous vs. intraperitoneal deferoxamine

, 1986
Aluminum removal by peritoneal dialysis: Intravenous vs. intraperitoneal deferoxamine. Aluminum removal via peritoneal dialysis was evaluated after the administration of deferoxamine in patients treated with CAPD and CCPD.
Norris, Keith C., Hercz, Gavril, Salusky, Isidro B., Fine, Richard N., Coburn, Jack W.   +4 more
core   +1 more source

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Efficacy of intramuscular and intraperitoneal deferoxamine for aluminum chelation

, 1987
Efficacy of intramuscular and intraperitoneal deferoxamine for aluminum chelation. As intravenous administration of deferoxamine is difficult in home dialysis patients we set out to determine the efficacy of intramuscular (i.m.) and intraperitoneal (i.p.)
Hasbargen, James A., Miller, Nancy L., Alfrey, Allen C., Molitoris, Bruce A., Alfrey, Patricia S., Kaehney, William D., Smith, Barbara J.   +6 more
core   +1 more source

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source

In-vitro Apoptotic Effects of Deferoxamine on the Glioblastoma Cell Line

Iranian South Medical Journal, 2019
Background: Research suggests the inhibitory effects of deferoxamine as an iron chelator on erythroleukemia cells. The present study was conducted to investigate the effects of deferoxamine on B92 cells as a model of glial cells carcinoma.
Mahtab Pourkamalzadeh, Seyid Mesam Abtahi froushani   +1 more
doaj  

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

The Availability of Iron Is Involved in the Murine Experimental Toxoplasma gondii Infection Outcome

Microorganisms, 2020
Iron is an important constituent of our environment, being necessary for both mammalian and pathogenic protozoa survival. Iron-containing proteins exert a wide range of biological processes such as biodegradation and biosynthesis, as well as immune ...
Mário Cézar Oliveira, Loyane Bertagnolli Coutinho, Marcos Paulo Oliveira Almeida, Marisol Pallete Briceño, Ester Cristina Borges Araujo, Neide Maria Silva   +5 more
doaj   +1 more source