Results 31 to 40 of about 18,326 (214)

N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson’s Disease

Antioxidants, 2020
Oxidative stress is a key mediator in the development and progression of Parkinson’s disease (PD). The antioxidant N-acetylcysteine (NAC) has generated interest as a disease-modifying therapy for PD but is limited due to poor bioavailability, a short ...
Leah Mursaleen, Brendon Noble, Stefanie Ho Yi Chan, Satyanarayana Somavarapu, Mohammed Gulrez Zariwala   +4 more
doaj   +1 more source

Value of black blood T2*cardiovascular magnetic resonance. [PDF]

, 2011
Purpose To assess whether black blood T2* cardiovascular magnetic resonance is superior to conventional white blood imaging of cardiac iron in patients with thalassaemia major (TM).
Gillian C Smith, Alam, MH, Mohammed H Alam, Firmin, DN, Carpenter John Paul, Alam Mohammed H, He, T, Smith Gillian C, Taigang He, Pennell, DJ, Firmin David N, Smith, GC, Carpenter, JP, Pennell Dudley J, Dudley J Pennell, David N Firmin, John Paul Carpenter, He Taigang   +17 more
core   +1 more source

How to Improve the Antioxidant Defense in Asphyxiated Newborns—Lessons from Animal Models

Antioxidants, 2020
Oxygen free radicals have been implicated in brain damage after neonatal asphyxia. In the early phase of asphyxia/reoxygenation, changes in antioxidant enzyme activity play a pivotal role in switching on and off the cascade of events that can kill the ...
Hanna Kletkiewicz, Maciej Klimiuk, Alina Woźniak, Celestyna Mila-Kierzenkowska, Karol Dokladny, Justyna Rogalska   +5 more
doaj   +1 more source

Deferoxamine Preventable Hepatocellular Damage, Following Hemorrhagic Shock [PDF]

, 2016
To examine the role of iron in mediating hepatocellular damage during reperfusion after hemorrhagic shock, we studied five groups of n=4 or 5 dogs, bled to reduce mean arterial pressure to 35 mmHg (± 5mrnHg) for three hours and subsequently treated 20 ...
Babbs, Charles F., Griffin, David W.
core   +1 more source

Designing Deferoxamine-Loaded Flaxseed Gum and Carrageenan-Based Controlled Release Biocomposite Hydrogel Films for Wound Healing

Gels, 2022
In this study, biocomposite hydrogel films made from flaxseed gum (FSG)/kappa carrageenan (CGN) were fabricated, using potassium chloride as a crosslinker and glycerol as a plasticizer.
Tayyaba Sadiq, Syed Haroon Khalid, Ikram Ullah Khan, Hira Mahmood, Sajid Asghar   +4 more
doaj   +1 more source

Acute renal failure following deferoxamine overdose [PDF]

, 2003
A 17-year-old patient with sickle cell-beta thalassemia undergoing treatment with home iron chelation therapy inadvertently received ten times the recommended dose of intravenous deferoxamine. Acute renal failure (ARF) developed within hours.
Flynn, Joseph T., Prasannan, Latha, Levine, John E.   +2 more
core   +1 more source

Comparison of deferasirox and deferoxamine effects on iron overload and immunological changes in patients with blood transfusion-dependent β-thalassemia

Asian Journal of Transfusion Science, 2017
Introduction: Beta-thalassemias are a cluster of inherited (autosomal recessive) hematological disorders prevalent in the Mediterranean area due to defects in synthesis of β chains of hemoglobin.
Hayder M Al-Kuraishy, Ali I Al-Gareeb
doaj   +1 more source

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

Advanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang, Xiangyang Zhan, Jiexiang Zhang, Mingyue Tan, Chuanmin Chu, Guanqun Ju, Xinyu Zhai, Jianyi Gu, Huirong Zhu, Dongliang Xu   +9 more
wiley   +1 more source

Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats.

, 1994
Iron catalyzes the formation of damaging reactive species during cerebral reperfusion. Brain iron concentration is highest at birth, so the brain of the asphyxiated newborn may be at increased risk of iron-dependent injury.
C Bero, R L Roberts, C Palmer
core   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source