Caspian Journal of Internal Medicine, 2017 Background: Cardiac complications due to iron overload are the most common cause of death in patients with thalassemia major. The aim of this study was to compare iron chelation effects of deferoxamine, deferasirox, and combination of deferoxamine and ...
Shahla Ansari +4 more
doaj +1 more source
International Journal of NanomedicineYiming Huang,1,* Xinran Wang,1,* Wenjing Li,1,* Feng Yue,1,2 Miao Wang,1 Feifan Zhou1,2 1State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Sanya, People’s Republic of China; 2One Health ...
Huang Y +5 more
doaj +2 more sources
Restoring the Angiogenic Capacity of the Human Diabetic Adipose-derived mesenchymal stem cells Primed with Deferoxamine as a Hypoxia Mimetic Agent: Role of HIF-1α [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: Insufficient angiogenesis is associated with serious diabetic complications. Recently, adipose-derived mesenchymal stem cells (ADScs) are known to be a promising tool causing therapeutic neovascularization.
Raziye Tajali +4 more
doaj +1 more source
Deferoxamine deconditioning increases neuronal vulnerability to hemoglobin
, 2020 Hypothesis: Deferoxamine pretreatment and abrupt withdrawal increases the vulnerability of neurons to hemoglobin. Model: Primary cortical cell cultures (murine); cultures were pretreated with deferoxamine alone, deferoxamine plus hemoglobin, or vehicle ...
Regan, R (via Mendeley Data)
core +3 more sources
The Role of Deferoxamine and Quercetin on The Short Term Chronic Toxicity of Iron on The Pituitary, Ovaries and Uterus of Prepubertal Albino Rats [PDF]
Zagazig Journal of Forensic Medicine and Toxicology, 2020 Iron is an important metal for Hypothalamic-pituitary-gonadal axis. Deferoxamine used as a potent antioxidant plus its chelating function. Quercetin is an effective antioxidant and also reported to have estrogenic activities. The aim of this study was to
Omnia Megahed +3 more
doaj +1 more source
Deferoxamine Improves Radiation-Induced Peripheral Neuropathy. [PDF]
J Cell Mol MedABSTRACT Radiation‐induced peripheral neuropathy (RIPN) is a devastating sequela of radiation therapy (XRT). Current treatment options are limited. Deferoxamine (DFO) has been useful in treating radiation‐induced dermal fibrosis. This study aimed to evaluate DFO for RIPN. Thus, 18 mice received 30Gy of fractionated XRT.
Lavin CV +12 more
europepmc +2 more sources
Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity [PDF]
, 2020 Background: Reduced glutathione and excess free iron within dopaminergic, substantia nigra neurons in Parkinson's disease (PD) can drive accumulation of toxic hydroxyl radicals resulting in sustained oxidative stress and cellular damage.
Zariwala, M. +2 more
core +1 more source
Reduced sulfatide content in deferoxamine-induced senescent HepG2 cells [PDF]
, 2023 Iron chelators, such as deferoxamine, exert an anticancer effect by altering the activity of biomolecules critical for regulation of the cell cycle, cell metabolism, and apoptotic processes.
Bresci, Arianna +15 more
core +1 more source
An overview of complications associated with deferoxamine therapy in thalassemia [PDF]
Journal of Nephropharmacology, 2021 Thalassemic syndromes are the most common genetic diseases in the world that are related to blood transfusion and iron overload in the body. In ß-thalassemia major multiple blood transfusions due to ineffective erythropoiesis lead to iron excess in the ...
Bijan Keikhaei +5 more
doaj +1 more source
Value of black blood T2*cardiovascular magnetic resonance. [PDF]
, 2011 Purpose To assess whether black blood T2* cardiovascular magnetic resonance is superior to conventional white blood imaging of cardiac iron in patients with thalassaemia major (TM).
Gillian C Smith +17 more
core +1 more source