Results 71 to 80 of about 16,909 (214)

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Intraperitoneal deferoxamine therapy for iron overload in children undergoing CAPD

, 1989
Intraperitoneal deferoxamine therapy for iron overload in children undergoing CAPD. We treated three children with renal failure and chronic iron overload with intraperitoneal deferoxamine therapy. Each child had an elevated serum ferritin level, a dense
Andreoli, Sharon P., Cohen, Mervyn
core   +1 more source

AKR1C3 Binds β‐Trcp to Promote the Degradation of TFRC to Protect Hepatocellular Carcinoma From Ferroptosis

Cancer Science, EarlyView.
In this study, we show that aldo‐keto reductase family 1 member C3 (AKR1C3), a protein highly expressed in ferroptosis resistant hepatocellular carcinoma cells, acts as an enzyme‐independent scaffold protein by promoting the nuclear export of β‐transducin repeat protein (β‐TrCP) and its binding to transferrin receptor (TFRC) in an enzyme‐independent ...
Lei Qi, Jingyi Hua, Di Pan, Wanwan Yang, Geng Tian, Fangyu Ye, Lingxiang Liu, Yuhan Mao, Qinglong Guo, Haopeng Sun, Li Zhao   +10 more
wiley   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Deferoxamine Preventable Hepatocellular Damage, Following Hemorrhagic Shock

, 2016
To examine the role of iron in mediating hepatocellular damage during reperfusion after hemorrhagic shock, we studied five groups of n=4 or 5 dogs, bled to reduce mean arterial pressure to 35 mmHg (± 5mrnHg) for three hours and subsequently treated 20 ...
Babbs, Charles F., Griffin, David W.
core  

Bone histologic response to deferoxamine in aluminum–related bone disease

, 1987
Bone histologic response to deferoxamine in aluminum–related bone disease. We have examined the changes in bone histology in 28 uremic patients after long–term treatment with the aluminum chelator, deferoxamine.
Endres, David B., Sherrard, Donald J., Alfrey, Allen C., Andress, Dennis L., Nebeker, Henry G., Ott, Susan M., Slatopolsky, Eduardo A., Coburn, Jack W.   +7 more
core   +1 more source

Deferoxamine Inhibits Canine Parvovirus by Suppressing Ferroptosis and Viral Replication

Veterinary Sciences
CPV is a highly pathogenic virus that enters host cells via the TFR, but its pathogenic mechanisms are not fully understood. In this study, we demonstrated that CPV infection induces ferroptosis in CRFK cells, characterized by elevated lipid peroxidation,
Kai Yu, Haoyuan Ma, Siqi Zhang, Jiawei Zhao, Jingrui Hao, Jialiang Xie, Hao Yu, Jianyou Jin, Xinpeng Ji, Shuoning Cao, Zheng Sun, Shujiang Xue, Shengwei Ji, Zhiqiang Xu, Chenghui Li, Rui Du, Xu Gao   +16 more
doaj   +1 more source

Toward optimizing the use of deferasirox: potential benefits of combined use with deferoxamine

Haematologica, 2013
Patients with β-thalassemia require iron chelation therapy to protect against progressive iron overload and non-transferrin-bound iron. Some patients fail to respond adequately to deferoxamine and deferasirox monotherapy while others have side effects ...
Robert W. Grady, Renzo Galanello, Rachel E. Randolph, Dorothy A. Kleinert, Carlo Dessi, Patricia J. Giardina   +5 more
doaj   +1 more source

Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Hemodialysis International, EarlyView.
ABSTRACT Background Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion‐related overload, remains unclear in chronic kidney disease. Aim To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.
Humam Emad Rajha, Richard Shamoon, Ameer Almeshagbeh, Samah Masry, Fadel Alqatati, Baha H. Abuajameia, Abdulqadir J. Nashwan   +6 more
wiley   +1 more source

Deferoxamine Reduces Early Metabolic Failure Associated With Severe Cerebral Ischemic Acidosis in Dogs

, 1995
Background and Purpose Postischemic metabolic injury may be mediated by acidosis and tissue bicarbonate depletion, with consequent iron mobilization and oxygen radical formation during reperfusion.
Kathleen K. Blizzard, Raymond C. Koehler, Patricia D. Hurn, Richard J. Traystman   +3 more
core   +1 more source