Results 71 to 80 of about 16,985 (220)

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

PROTECTIVE EFFECT OF THE IRON CHELATOR DEFEROXAMINE ON CEREBRAL VASOSPASM [PDF]

, 1992
Experimental studies suggest the primary role of free radical products in the development of vasospasm. In the present study, the iron chelator deferoxamine was used at the time of subarachnoid hemorrhage to prevent chronic cerebral vasospasm.
KILINC, K, SENAATI, S, CANER, H, BENLI, K, BOLAY, HAYRUNNİSA BOLAY   +4 more
core   +1 more source

Use of deferoxamine (DFO) in transfusion-dependent β-thalassemia during pregnancy: A retrospective study

Taiwanese Journal of Obstetrics & Gynecology, 2020
Objective: To report cases of use of chelation therapy during pregnancy which resulted in favorable outcomes for the babies. Materials and methods: In this retrospective cohort study, we described the evolution and outcome of 9 pregnancies in Italian ...
Maria Grazia Piccioni, Carmela Capone, Flaminia Vena, Valentina Del Negro, Michele Carlo Schiavi, Valentina D'Ambrosio, Antonella Giancotti, Maria Paola Smacchia, Roberto Brunelli   +8 more
doaj   +1 more source

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

The effect of deferoxamine on fat graft survival in tamoxifen use: An experimental study

Turkish Journal of Plastic Surgery
Introduction: Autologous fat graft survival depends on many variables such as vascularization and inflammation. Fat grafts are also frequently used in breast reconstructions. Objective: The objective is to investigate the effect of tamoxifen (TAM), which
Burak Yasar, Ramazan Erkin Ünlü
doaj   +1 more source

Revertant Mosaicism Obscures Long‐Awaited Molecular Confirmation of Diamond‐Blackfan Anemia

American Journal of Medical Genetics Part A, EarlyView.
Nicholas A. Borja, Mustafa Tekin
wiley   +1 more source

Retinal dystrophies simulating geographic atrophy: A diagnostic challenge

Acta Ophthalmologica, EarlyView.
Abstract Geographic atrophy (GA) is the chronic loss of retinal pigment epithelium, photoreceptors and choriocapillaris, marking the dry late stage of age‐related macular degeneration (AMD). GA prevalence is expected to rise in the upcoming decades. Advanced GA leads to central scotomas, reducing visual acuity and quality of life, potentially resulting
Johanna M. Colijn, Frank G. Holz, Jeroen Pas, Carel Hoyng   +3 more
wiley   +1 more source

Structural evolution of aragonite superstructures obtained in the presence of the siderophore deferoxamine [PDF]

, 2015
International audienceThe effect of amphoteric siderophore deferoxamine on the crystallization behavior of calcium carbonate was investigated under bioinspired conditions.
Pinna, N., Antonietti, M., Cölfen, H., Nassif, Nadine, Pinna, Nicola, Nassif, N., Polleux, Julien, Willinger, M., Willinger, Marc-Georg, Cölfen, Helmut, Polleux, J., Antonietti, Markus   +11 more
core   +2 more sources

Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer

Cancer Science, EarlyView.
The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang, Puyuan Chen, Yawen Zheng, Feiyue Shi, Min Wang, Luwei Xu, Xiaowei Wei, Xiumei Wang   +7 more
wiley   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source