Results 61 to 70 of about 1,341 (126)

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Long-term myopia control effect and safety in children wearing DIMS spectacle lenses for 6 years

Scientific Reports, 2023
This study evaluated the long-term myopia control effect and safety in children wearing Defocus Incorporated Multiple Segments (DIMS) spectacle lenses.
Carly Siu Yin Lam, Wing Chun Tang, Han Yu Zhang, Paul H. Lee, Dennis Yan Yin Tse, Hua Qi, Natalia Vlasak, Chi Ho To   +7 more
doaj   +1 more source

Polarization Holographic 4D Phenotyping Reveals Nanoplastic Induced Dysfunction in Zooplankton

Advanced Science, EarlyView.
Contaminant‐induced dysfunction in complex aquatic organisms remains difficult to resolve across scales. Polarization Holographic Imaging Microscopy (PHIM) integrates polarization‐sensitive holography with computational volumetric reconstruction for label‐free phenotyping of zooplankton in natural seawater, revealing that nanoplastic stress drives ...
Yuxing Li, Yanmin Zhu, Jingyan Chen, Rongzhou Chen, Yuen‐Wa Ho, Chutian Wang, James Kar‐Hei Fang, Kevin K. Tsia, Edmund Y. Lam   +8 more
wiley   +1 more source

One-Year Results of Orthokeratology and Defocus Incorporated Multiple Segment Lenses in French Children for Myopia Control

Cureus
Purpose Myopia is a common refractive error affecting vision. This study aims to evaluate two real-world methods for myopia control: orthokeratology (ortho-k) and defocus incorporated multiple segment (DIMS) spectacles lenses. Methods This retrospective observational multicenter study was conducted on a French population with myopia, treated with ...
Boulanger, Florent, Poret, Julien, Liu, Pan, Jany, Benjamin, Bui Quoc, Emmanuel, Tran, Thi Ha Chau   +5 more
openaire   +2 more sources

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Cr1/4NbSe2‐Single Crystal Growth and Evolution of Antiferromagnetic Correlated States

Advanced Science, EarlyView.
High‐quality single crystals Cr1/4NbSe2 were synthesized and comprehensively characterized for the first time. Advanced structural, electronic, and magnetic measurements uncover a correlated antiferromagnetic state, resolving longstanding inconsistencies regarding magnetic behavior derived from earlier polycrystal studies.
Nour Abdelrahman, Bastian Rubrecht, Matheus Felipe de Souza Barbosa, Mahdi Behnami, Dmitriy Efremov, Daniel Wolf, Martin Valldor, Alexey A. Popov, Stanislav M. Avdoshenko, Marco Naumann, Martin Knupfer, Vladislav Kataev, Alexey Alfonsov, Anja U. B. Wolter, Michael Mertig, Bernd Büchner, Silke Hampel   +16 more
wiley   +1 more source

Automated Bacterial Identification and Morphological Feature Analysis in Low‐Dose Cryo‐EM Using YOLOv11

Advanced Intelligent Discovery, EarlyView.
AI‐based tools enable rapid characterization of bacterial ultrastructure in low‐dose cryogenic transmission electron microscopy. The envelope thickness tool quantifies membrane thickness and anisotropy. The flagella module analyzes filament morphology and detects cell‐flagella contacts.
Sita Sirisha Madugula, Lynnicia N. Massenburg, Spenser R. Brown, Amber N. Bible, Chanda R. Harris, Lance X. Zhang, Kiara Parker, Scott T. Retterer, Jennifer L. Morrell‐Falvey, Rama K. Vasudevan, Alexis N. Williams   +10 more
wiley   +1 more source

Skin‐Conformal Myography for Real‐Time Hand Tracking Using a Laser‐Induced Graphene Strain Sensor Array

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
A skin‐conformal wearable device based on laser‐induced graphene is developed for continuous strain measurement across the circumference of the forearm for gesture recognition and hand‐tracking applications. Post material optimization, the strain sensor array is integrated with a wearable wireless readout circuit for real‐time control of a robotic arm,
Vinay Kammarchedu, Monther AlSiyabi, Aida Ebrahimi   +2 more
wiley   +1 more source

Comparative effectiveness of dual-focus contact lenses and DIMS spectacle lenses for myopia control in patients with low astigmatism: a retrospective study

Frontiers in Medicine
PurposeThis study aimed to evaluate and compare the effectiveness of dual-focus contact lenses (DFCL) and defocus incorporated multiple segment (DIMS) spectacle lenses in controlling myopia progression in patients with low astigmatism.MethodsA ...
Chia-Yi Lee, Chia-Yi Lee, Chia-Yi Lee, Shun-Fa Yang, Shun-Fa Yang, Yu-Ling Chang, Jing-Yang Huang, Ie-Bin Lian, Chao-Kai Chang, Chao-Kai Chang   +9 more
doaj   +1 more source