Results 1 to 10 of about 5,241 (151)

Deformation-based morphometry identifies deep brain structures protected by ocrelizumab [PDF]

NeuroImage: Clinical, 2022
Background: Despite advancements in treatments for multiple sclerosis, insidious disease progression remains an area of unmet medical need, for which atrophy-based biomarkers may help better characterize the progressive biology. Methods: We developed and
Zhuang Song, Anithapriya Krishnan, Laura Gaetano, Nicholas J. Tustison, David Clayton, Alex de Crespigny, Thomas Bengtsson, Xiaoming Jia, Richard A.D. Carano   +8 more
doaj   +6 more sources

Characterization of dynamic patterns of human fetal to neonatal brain asymmetry with deformation-based morphometry [PDF]

Frontiers in Neuroscience, 2023
IntroductionDespite established knowledge on the morphological and functional asymmetries in the human brain, the understanding of how brain asymmetry patterns change during late fetal to neonatal life remains incomplete.
Céline Steger, Céline Steger, Céline Steger, Céline Steger, Charles Moatti, Charles Moatti, Kelly Payette, Kelly Payette, Alexandra De Silvestro, Alexandra De Silvestro, Alexandra De Silvestro, Thi Dao Nguyen, Seline Coraj, Ninib Yakoub, Giancarlo Natalucci, Giancarlo Natalucci, Raimund Kottke, Ruth Tuura, Ruth Tuura, Walter Knirsch, Walter Knirsch, Andras Jakab, Andras Jakab, Andras Jakab   +23 more
doaj   +7 more sources

Deformation based morphometry study of longitudinal MRI changes in behavioral variant frontotemporal dementia [PDF]

NeuroImage: Clinical, 2019
Objective: To objectively quantify how cerebral volume loss could assist with clinical diagnosis and clinical trial design in the behavioural variant of frontotemporal dementia (bvFTD).
Ana L. Manera, Mahsa Dadar, D. Louis Collins, Simon Ducharme   +3 more
doaj   +6 more sources

Morphological Changes of Frontal Areas in Male Individuals With HIV: A Deformation-Based Morphometry Analysis [PDF]

Frontiers in Neurology, 2022
ObjectivePrevious studies on HIV-infected (HIV+) individuals have revealed brain structural alterations underlying HIV-associated neurocognitive disorders. Most studies have adopted the widely used voxel-based morphological analysis of T1-weighted images
Guochao Chen, Guochao Chen, Dan-Chao Cai, Fengxiang Song, Yi Zhan, Lei Wei, Chunzi Shi, He Wang, He Wang, Yuxin Shi, Yuxin Shi   +10 more
doaj   +4 more sources

Regional Volume Decreases in the Brain of Pax6 Heterozygous Mutant Rats: MRI Deformation-Based Morphometry. [PDF]

PLoS ONE, 2016
Pax6 is a transcription factor that pleiotropically regulates various developmental processes in the central nervous system. In a previous study, we revealed that Pax6 heterozygous mutant (rSey2/+) adult rats exhibit abnormalities in social interaction ...
Kotaro Hiraoka, Akira Sumiyoshi, Hiroi Nonaka, Takako Kikkawa, Ryuta Kawashima, Noriko Osumi   +5 more
doaj   +5 more sources

Deformation-based morphometry applied to FDG PET data reveals hippocampal atrophy in Alzheimer’s disease [PDF]

Scientific Reports
Cerebral atrophy is a key finding in patients with dementia and usually determined on MRI. We tested whether cerebral atrophy can be imaged with FDG PET by applying deformation-based morphometry (DBM).
Lars Frings, Ganna Blazhenets, Joachim Brumberg, Alexander Rau, Horst Urbach, Philipp T. Meyer   +5 more
doaj   +5 more sources

Deformation-based morphometry: a sensitive imaging approach to detect radiation-induced brain injury? [PDF]

Cancer Imaging
Background Radiotherapy is a major therapeutic approach in patients with brain tumors. However, it leads to cognitive impairments. To improve the management of radiation-induced brain sequalae, deformation-based morphometry (DBM) could be relevant. Here,
Carole Brunaud, Samuel Valable, Gwenn Ropars, Fatima-Azzahra Dwiri, Mikaël Naveau, Jérôme Toutain, Myriam Bernaudin, Thomas Freret, Marianne Léger, Omar Touzani, Elodie A. Pérès   +10 more
doaj   +6 more sources

Effect of nonrigid registration algorithms on deformation-based morphometry: a comparative study with control and Williams syndrome subjects [PDF]

Magnetic Resonance Imaging, 2012
Deformation-based morphometry (DBM) is a widely used method for characterizing anatomical differences across groups. DBM is based on the analysis of the deformation fields generated by nonrigid registration algorithms, which warp the individual volumes to a DBM atlas.
Thornton-Wells T A, Elisabeth Dykens
exaly   +5 more sources

A Unified Statistical Approach to Deformation-Based Morphometry [PDF]

NeuroImage, 2001
We present a unified statistical framework for analyzing temporally varying brain morphology using the 3D displacement vector field from a nonlinear deformation required to register a subject's brain to an atlas brain. The unification comes from a single model for structural change, rather than two separate models, one for displacement and one for ...
D Louis Collins, Moo Chung, Alan Evans
exaly   +3 more sources

Deformation-based surface morphometry applied to gray matter deformation [PDF]

NeuroImage, 2003
We present a unified statistical approach to deformation-based morphometry applied to the cortical surface. The cerebral cortex has the topology of a 2D highly convoluted sheet. As the brain develops over time, the cortical surface area, thickness, curvature, and total gray matter volume change. It is highly likely that such age-related surface changes
Jonathan Taylor, Jay Giedd, Tomáš Paus   +2 more
exaly   +3 more sources