Results 61 to 70 of about 57,363 (292)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Degeneracy in the Blasius problem

Electronic Journal of Differential Equations, 2007
The Navier-Stokes equations for the boundary layer are transformed, by a similarity transformation, into the ordinary Blasius differential equation which, together with appropriate boundary conditions constitutes the Blasius problem, $$ f'''(
Faiz Ahmad
doaj  

Degeneracy of decadent dyons [PDF]

Journal of High Energy Physics, 2008
A quarter-BPS dyon in $\mathcal{N}=4$ super Yang-Mills theory is generically `decadent' in that it is stable only in some regions of the moduli space and decays on submanifolds in the moduli space. Using this fact, and from the degeneracy of the system close to the decay, a new derivation for the degeneracy of such dyons is given.
Dabholkar, Atish, Narayan, K., Nampuri, Suresh   +2 more
openaire   +4 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Sharp viscous shock waves for relaxation model with degeneracy

Advances in Nonlinear Analysis
This article is concerned with a relaxation model with degeneracy. Different from the existing studies on the regular viscous shock waves, we recognize that when the sub-characteristic condition is degenerate, the dynamical system possesses sharp viscous
Xu Shufang, Mei Ming, Sheng Wancheng, Wang Zejia   +3 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

CP Degeneracy in Tensor Regression [PDF]

, 2020
Tensor linear regression is an important and useful tool for analyzing tensor data. To deal with high dimensionality, CANDECOMP/PARAFAC (CP) low-rank constraints are often imposed on the coefficient tensor parameter in the (penalized) $M$-estimation ...
Zhou, Ya, Wong, Raymond K. W., He, Kejun, Ya Zhou, Kejun He, Raymond K. W. Wong   +5 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The CMB neutrino mass/vacuum energy degeneracy: a simple derivation of the degeneracy slopes [PDF]

, 2018
This is a pre-copyedited, author-produced PDF of an article accepted for publication in Monthly Notices of the Royal Astronomical Society, following peer review. The version of record Sutherland, W. (2018). "The CMB neutrino mass/vacuum energy degeneracy:
Will Sutherland, Sutherland, W
core   +1 more source