Results 81 to 90 of about 57,363 (292)

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Exaptation, Degeneracy and Innovation [PDF]

In innovation processes, exaptations are innovation-development processes through which an initial attribution of new functionality to existing artifacts leads to new artifacts and eventually new markets.
Giovanni Bonifati
core  

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Uniqueness of solutions to a system of differential inclusions

Electronic Journal of Differential Equations, 2000
In this paper we study the uniqueness of solutions to the initial and Dirichlet boundary-value problem of differential inclusions $$ Delta u_i+ablacdotvec {B_i} (u_1,u_2,dots,u_N)in {partial F_i(u_i) over partial t}, quad i=1,2,dots,N, $$ where $vec{B_i}(
Chunpeng Wang, Jingxue Yin
doaj  

Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs

eLife
Nociceptive sensory neurons convey pain-related signals to the CNS using action potentials. Loss-of-function mutations in the voltage-gated sodium channel NaV1.7 cause insensitivity to pain (presumably by reducing nociceptor excitability) but clinical ...
Yu-Feng Xie, Jane Yang, Stéphanie Ratté, Steven A Prescott   +3 more
doaj   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Degeneracy in infinite horizon optimization [PDF]

, 1989
We consider sequential decision problems over an infinite horizon. The forecast or solution horizon approach to solving such problems requires that the optimal initial decision be unique.
Bean, James C., James C. Bean, Ryan, Sarah McAllister, Sarah M. Ryan   +3 more
core   +1 more source

Octant Degeneracy and Plots of Parameter Degeneracy in Neutrino Oscillations Revisited [PDF]

The three kinds of parameter degeneracy in neutrino oscillation, the intrinsic, sign and octant degeneracy, form an eight-fold degeneracy. The nature of this eight-fold degeneracy can be visualized on the ($\sin^22\theta_{13}$, $1/\sin^2\theta_{23 ...
Yasuda, Osamu, Sugama, Sho
core   +1 more source

Benchmarking antibody discovery fidelity and reproducibility with an assay-locked residue fidelity index

BioTechniques
Reproducibility in antibody discovery is undermined by dropout, paratope degeneracy, and immunogen imprinting. Although guidelines exist, the field lacks a shared, assay-locked metric to benchmark these liabilities across discovery pipelines.
Michael P. Weiner
doaj   +1 more source

Filtering Statistics on Networks

Entropy, 2020
Compression, filtering, and cryptography, as well as the sampling of complex systems, can be seen as processing information. A large initial configuration or input space is nontrivially mapped to a smaller set of output or final states.
G. J. Baxter, R. A. da Costa, S. N. Dorogovtsev, J. F. F. Mendes   +3 more
doaj   +1 more source