Results 11 to 20 of about 696,209 (319)

Modelling the Genetic Risk in Age-Related Macular Degeneration [PDF]

, 2012
Late-stage age-related macular degeneration (AMD) is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians.
Weber, Bernhard H. F., Lars G. Fritsche, Weber, Bernhard H.F., Bernhard H. F. Weber, Grassmann, F., Iris M Heid, Grassmann, Felix, Lars G Fritsche, Fritsche Lars G., Keilhauer Claudia N., Keilhauer, Claudia N., Claudia N. Keilhauer, Claudia N. Keilhauer (162279), Heid, I.M., Heid, Iris M., Felix Grassmann, Felix Grassmann (162264), Fritsche, Lars G., Keilhauer, C.N., Claudia N Keilhauer, Iris M. Heid, Weber, B.H.F., Bernhard H F Weber, Grassmann Felix, Lars G. Fritsche (162272), Fritsche, L.G., Bernhard H. F. Weber (162289), Heid Iris M., Weber Bernhard H. F., Iris M. Heid (87553)   +29 more
core   +1 more source

Delusions in frontotemporal lobar degeneration [PDF]

, 2009
We assessed the significance and nature of delusions in frontotemporal lobar degeneration (FTLD), an important cause of young-onset dementia with prominent neuropsychiatric features that remain incompletely characterised.
Nick C. Fox, Fox, N.C.I., Rossor, M.N., Rohani Omar, Warren, J.D., Mummery, C.J., Fox, N.C., Elizabeth L. Sampson, Sampson, E.L., Loy, C.T., Martin N. Rossor, Catherine J. Mummery, Omar, R., Jason D. Warren, Clement T. Loy   +14 more
core   +1 more source

Patterns of Microglial Cell Activation in Frontotemporal Lobar Degeneration [PDF]

, 2013
AIMS: Pathological heterogeneity within patients with Frontotemporal lobar degeneration (FTLD) in general precludes the accurate assignment of diagnostic subtype in life.
Pickering-Brown, Stuart, Snowden, Julie S, Robinson, Andrew C, Thompson, Jennifer C, Rollinson, Sara, Mann, David MA, Gerhard, Alexander, Mann, David M A, Davidson, Yvonne S, Robinson, Andrew C; id_orcid, Lant, Suzannah B   +10 more
core   +1 more source

Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects

Bioactive Materials, 2023
Injectable bone biomaterials like bone cement should be designed and fabricated with certain biological criteria, which include: 1) recruitment and polarization of the macrophages from M1 (pro-inflammatory) to M2 (anti-inflammatory) phenotype, 2) enhance
Shuaijie Li, Liyan Zhang, Chunyu Liu, Jua Kim, Kun Su, Tingli Chen, Limin Zhao, Xiaomei Lu, Hao Zhang, Yinglin Cui, Xu Cui, Feng Yuan, Haobo Pan   +12 more
doaj   +1 more source

Circular RNA circSIPA1L1 Contributes to Osteosarcoma Progression Through the miR-411-5p/RAB9A Signaling Pathway

Frontiers in Cell and Developmental Biology, 2021
Recently, various studies have identified circular RNAs (circRNAs) to play a significant role in tumorigenesis, thereby showing potential as novel tumor biomarkers.
Yining Xu, Yining Xu, Teng Yao, Haonan Ni, Rujie Zheng, Kangmao Huang, Yizhen Huang, Jun Gao, Di Qiao, Di Qiao, Shuying Shen, Jianjun Ma, Jianjun Ma   +12 more
doaj   +1 more source

A channel for degeneration [PDF]

Nature Reviews Neuroscience, 2020
In flies, mutant TRPV4 causes mitochondrial transport deficits, axonal degeneration and neuronal dysfunction.
openaire   +2 more sources

Protective Effects of Curcumin in Cardiovascular Diseases—Impact on Oxidative Stress and Mitochondria

Cells, 2022
Cardiovascular diseases (CVDs) contribute to a large part of worldwide mortality. Similarly, two of the major risk factors for these diseases, aging and obesity, are also global problems.
Fiona Frederike Cox, Angelina Misiou, Annika Vierkant, Niloofar Ale-Agha, Maria Grandoch, Judith Haendeler, Joachim Altschmied   +6 more
doaj   +1 more source

The M-CSF receptor in osteoclasts and beyond

Experimental and Molecular Medicine, 2020
Bone disease: Signaling pathway offers promising drug target Drugs directed at a key signaling receptor involved in breaking down bone tissue could help treat diseases marked by pathological bone loss and destruction. In a review article, Kyung-Hyun Park-
Se Hwan Mun, Peter Sang Uk Park, Kyung-Hyun Park-Min   +2 more
doaj   +1 more source

NRF2 Is an Upstream Regulator of MYC-Mediated Osteoclastogenesis and Pathological Bone Erosion

Cells, 2020
Osteoclasts are the sole bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathogenic bone destruction such as inflammatory arthritis.
Peter Sang Uk Park, Se Hwan Mun, Steven L. Zeng, Haemin Kim, Seyeon Bae, Kyung-Hyun Park-Min   +5 more
doaj   +1 more source

Comparisons of the Efficacy and Safety of Total Knee Arthroplasty by Different Surgical Approaches: A Systematic Review and Network Meta‐analysis

Orthopaedic Surgery, 2022
The purpose of this network meta‐analysis was to investigate the efficacy and safety of total knee arthroplasty (TKA) considering seven different surgical approaches.
Jin‐long Zhao, Ling‐feng Zeng, Jian‐ke Pan, Gui‐hong Liang, He‐tao Huang, Wei‐yi Yang, Ming‐hui Luo, Jun Liu   +7 more
doaj   +1 more source