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Advances in Mathematics, 2023 Computing all critical points of a monomial on a very affine variety is a fundamental task in algebraic statistics, particle physics and other fields. The number of critical points is known as the maximum likelihood (ML) degree. When the variety is smooth, it coincides with the Euler characteristic.
D. Agostini (Daniele) +6 more
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
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Age-related macular degeneration in the UK [PDF]
The aim of this thesis was to investigate the prevalence and impact of age-related macular degeneration (AMD) causing visual impairment in people aged 75 years and above in the UK.
Evans, Jennifer Rosemary
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Prevalence of age-related macular degeneration in Nakuru, Kenya: a cross-sectional population-based study. [PDF]
, 2013 BACKGROUND: Diseases of the posterior segment of the eye, including age-related macular degeneration (AMD), have recently been recognised as the leading or second leading cause of blindness in several African countries.
Peto, Tunde; id_orcid +24 more
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Spheroidal Degeneration in Two Siblings: Clinical and Histopathological Features [PDF]
, 2021 Spheroidal corneal degeneration is predominantly seen in advanced age and hereditary predisposition to this disorder is very rare. This report describes the occurrence of bilateral band-shaped spheroidal corneal degeneration in two ...
Isikci, Ozlem Tanas +11 more
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Limitations and modifications in the clinical application of calcium sulfate
Frontiers in SurgeryCalcium sulfate and calcium sulfate-based biomaterials have been widely used in non-load-bearing bone defects for hundreds of years due to their superior biocompatibility, biodegradability, and non-toxicity.
Deng-xing Lun +7 more
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THE EDUCATION OF THE DEGENERATE. [PDF]
JAMA: The Journal of the American Medical Association, 1901 Those nerve cells which are most active, develop most in increasing length and complexity of their dendritic branches. The development takes place during physical as well as mental activity, and the education of one cell group, directly stimulated, leads to the education of more or less remote cell groups, by reason of dendritis contact.
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A channel for degeneration [PDF]
Nature Reviews Neuroscience, 2020 In flies, mutant TRPV4 causes mitochondrial transport deficits, axonal degeneration and neuronal dysfunction.
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Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source