Results 51 to 60 of about 759,258 (311)

Role of mTORC1 activity during early retinal development and lamination in human-induced pluripotent stem cell‐derived retinal organoids

Cell Death Discovery, 2022
Retinal organoids derived from human-induced pluripotent stem cells (hiPSC) are powerful tools for studying retinal development as they model spatial and temporal differentiation of retinal cell types.
Si Hyung Lee, Jung Woo Han, Jin Young Yang, Hyoung Oh Jun, Ji Hong Bang, Heejeong Shin, Ji Hye Choi, Jongwoo Lee, Sanjar Batirovich Madrakhimov, Kyung Hwun Chung, Hun Soo Chang, Jungmook Lyu, Tae Kwann Park   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina [PDF]

, 2005
PURPOSE: Kinetic studies of photoreceptor cell death in the retinal degeneration (rd1) mouse model suggest that photoreceptor degeneration could result from cumulative damage.
Neveux, N, Forster, V, Picaud, S, Leveillard, T, Sahel, JA, Delyfer, MN   +5 more
core  

Effect of bisphosphonates on the risk of surgical site infection after anterior cervical discectomy and fusion (ACDF) in postmenopausal women with osteoporosis

BMC Women's Health
Objective To investigate the effect of bisphosphonates on surgical site infection (SSI) and their safety in postmenopausal women undergoing Anterior Cervical Discectomy and Fusion (ACDF).
Weilin Zhang, Boyuan Zhou, Canchang Chen, Dao Feng, Junyi Zhang, Zhencong Li, Jinguo Liang, Shengbang Huang, Zhiwen Dai, Cheng Luo, Jinsong Wei   +10 more
doaj   +1 more source

Effect of daphnetin combined with tobramycin on Pseudomonas aeruginosa biofilm infection in vitro and in vivo

Frontiers in Immunology
ObjectiveThe aim of this study was to investigate the effectiveness of daphnetin in combination with tobramycin on Pseudomonas aeruginosa biofilm infection in vitro and in vivo.MethodThe study was divided into four groups: control, tobramycin, daphnetin,
Dingbin Li, Chao Mao, Siyuan Chen, Zhongwei Wang, Weilin Zhang, Zhencong Li, Liangsheng Li, Chaoqin He, Weixiong Guo, Jinsong Wei, Qingjun Wei   +10 more
doaj   +1 more source

The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

Scientific Reports, 2021
Bacopa monnieri (Linn.) Wettst. has been used in traditional medicine as a drug to enhance and improve memory. In this regard, this study aims to provide B.
James M. Brimson, Sirikalaya Brimson, Mani Iyer Prasanth, Premrutai Thitilertdecha, Dicson Sheeja Malar, Tewin Tencomnao   +5 more
doaj   +1 more source

THE DEGENERATE TONSIL. [PDF]

JAMA: The Journal of the American Medical Association, 1903
Ablation of hypertrophied tonsils is a procedure which has become generally indorsed by the profession of medicine, though in earlier years its advocates were less numerous and many sturdy opponents contended that the proper course to pursue was to patiently await Nature's cure by absorption or, as most often worded, until the patient would outgrow the
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

An Ecological Correlation Study of Late Age-Related Macular Degeneration and the Complement Factor H Y402H Polymorphism

, 2009
PURPOSE: To investigate whether variation in the distribution of the risk allele frequency of the Y402H single-nucleotide polymorphism (SNP) across various ethnicities and geographic regions reflects differences in the prevalence of late age-related ...
Whittaker, John C, Sofat, Reecha, Smeeth, Liam, Nonyane, Bareng A.S., Chakravarthy, Usha, Fletcher, Astrid E., Whittaker, John C., Fletcher, Astrid E, Nitsch, Dorothea, Nonyane, Bareng AS   +9 more
core   +1 more source

Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration

Journal of Biological Engineering
Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus experienced hypoxic deterioration and the ...
Zhencong Li, Weilin Zhang, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Qiulan Qiu, Siyuan Chen, Weixiong Guo, Zhongwei Wang, Jinsong Wei   +9 more
doaj   +1 more source