Results 31 to 40 of about 1,040,463 (288)

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

Nature Communications, 2018
The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of ...
Upneet K. Sokhi, Mark P. Liber, Laura Frye, Sungho Park, Kyuho Kang, Tania Pannellini, Baohong Zhao, Rada Norinsky, Lionel B. Ivashkiv, Shiaoching Gong   +9 more
doaj   +1 more source

A novel magnetic resonance imaging postprocessing technique for the assessment of intervertebral disc degeneration-Correlation with histological grading in a rabbit disc degeneration model. [PDF]

, 2019
Introduction:Estimation of intervertebral disc degeneration on magnetic resonance imaging (MRI) is challenging. Qualitative schemes used in clinical practice correlate poorly with pain and quantitative techniques have not entered widespread clinical use.
Chamoli, Uphar, Diwan, Ashish D, Kato, Kenji, Masuda, Koichi, Miyazaki, Shingo, Sheldrick, Kyle   +5 more
core   +1 more source

Role of mTORC1 activity during early retinal development and lamination in human-induced pluripotent stem cell‐derived retinal organoids

Cell Death Discovery, 2022
Retinal organoids derived from human-induced pluripotent stem cells (hiPSC) are powerful tools for studying retinal development as they model spatial and temporal differentiation of retinal cell types.
Si Hyung Lee, Jung Woo Han, Jin Young Yang, Hyoung Oh Jun, Ji Hong Bang, Heejeong Shin, Ji Hye Choi, Jongwoo Lee, Sanjar Batirovich Madrakhimov, Kyung Hwun Chung, Hun Soo Chang, Jungmook Lyu, Tae Kwann Park   +12 more
doaj   +1 more source

On the Euler characteristic of Kronecker moduli spaces [PDF]

, 2012
Combining the MPS degeneration formula for the Poincar\'e polynomial of moduli spaces of stable quiver representations and localization theory, it turns that the determination of the Euler characteristic of these moduli spaces reduces to a combinatorial ...
Weist, Thorsten
core   +1 more source

Selenoprotein T Protects Endothelial Cells against Lipopolysaccharide-Induced Activation and Apoptosis

Antioxidants, 2021
Sepsis is an exaggerated immune response upon infection with lipopolysaccharide (LPS) as the main causative agent. LPS-induced activation and apoptosis of endothelial cells (EC) can lead to organ dysfunction and finally organ failure.
Dennis Merk, Johannes Ptok, Philipp Jakobs, Florian von Ameln, Jan Greulich, Pia Kluge, Kathrin Semperowitsch, Olaf Eckermann, Heiner Schaal, Niloofar Ale-Agha, Joachim Altschmied, Judith Haendeler   +11 more
doaj   +1 more source

Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]

, 2015
Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa, Megighian, Aram, Montecucco, Cesare, Pirazzini, Marco, Rigoni, Michela, Scorzeto, M., Zanetti, Giulia   +6 more
core   +2 more sources

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation

Nature Communications, 2019
Macrophage activation is synergistically controlled by lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Here the authors show that IFN-γ promotes macrophage activation not only by activating STAT1-dependent genes, but also by suppressing STAT3 ...
Kyuho Kang, Mahesh Bachu, Sung Ho Park, Keunsoo Kang, Seyeon Bae, Kyung-Hyun Park-Min, Lionel B. Ivashkiv   +6 more
doaj   +1 more source

The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

Scientific Reports, 2021
Bacopa monnieri (Linn.) Wettst. has been used in traditional medicine as a drug to enhance and improve memory. In this regard, this study aims to provide B.
James M. Brimson, Sirikalaya Brimson, Mani Iyer Prasanth, Premrutai Thitilertdecha, Dicson Sheeja Malar, Tewin Tencomnao   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Limitations and modifications in the clinical application of calcium sulfate

Frontiers in Surgery
Calcium sulfate and calcium sulfate-based biomaterials have been widely used in non-load-bearing bone defects for hundreds of years due to their superior biocompatibility, biodegradability, and non-toxicity.
Deng-xing Lun, Si-ying Li, Nian-nian Li, Le-ming Mou, Hui-quan Li, Wan-ping Zhu, Hong-fei Li, Yong-cheng Hu   +7 more
doaj   +1 more source