Results 61 to 70 of about 759,258 (311)

Polyethylene microplastics trigger osteosarcoma progression via ITGA5/FAPα/LGMN cancer promoting complex: A novel environmental cancer promoting mechanism

Ecotoxicology and Environmental Safety
This study seeks to elucidate the molecular mechanisms by which polyethylene microplastics (PE-MPs) facilitate the progression of osteosarcoma through the modulation of the ITGA5/FAPα/LGMN protein complex.
Weilin Zhang, Shengbang Huang, Kuize Liu, Dao Feng, Jinguo Liang, Zhencong Li, Boyuan Zhou, Zhiwen Dai, Zhongwei Wang, Jinsong Wei   +9 more
doaj   +1 more source

Selenoprotein T Protects Endothelial Cells against Lipopolysaccharide-Induced Activation and Apoptosis

Antioxidants, 2021
Sepsis is an exaggerated immune response upon infection with lipopolysaccharide (LPS) as the main causative agent. LPS-induced activation and apoptosis of endothelial cells (EC) can lead to organ dysfunction and finally organ failure.
Dennis Merk, Johannes Ptok, Philipp Jakobs, Florian von Ameln, Jan Greulich, Pia Kluge, Kathrin Semperowitsch, Olaf Eckermann, Heiner Schaal, Niloofar Ale-Agha, Joachim Altschmied, Judith Haendeler   +11 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Dissociating memory networks in early Alzheimer's disease and frontotemporal lobar degeneration - a combined study of hypometabolism and atrophy [PDF]

, 2013
Introduction: We aimed at dissociating the neural correlates of memory disorders in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD).
Barbara Vogt, Müller, Karsten, Becker, G., Dukart, J., Frisch, Stefan, Osama Sabri, Dukart, Jürgen, Horstmann, A., Schroeter, Matthias, Vogt, B., Sabri, O., Mueller, K. ; https://orcid.org/, Matthias L Schroeter, Barthel, H., Sabri, Osama, Juergen Dukart, Villringer, Arno, Karsten Müller, Villringer, A. ; https://orcid.org/, Henryk Barthel, Vogt, Barbara, Stefan Frisch, Becker, Georg, Frisch, S. ; https://orcid.org/, Annette Horstmann, Arno Villringer, Barthel, Henryk, Schroeter, M. ; https://orcid.org/, Horstmann, Annette, Georg Becker   +29 more
core   +2 more sources

The role of complement in synaptic degeneration

, 2012
Synapse loss is an early event of many neurodegenerative diseases including Alzheimer?s disease and Parkinson?s disease. The causes and mechanisms that underpin synapse dysfunction and degeneration are poorly understood.
Malfa, Katya
core   +1 more source

Simultaneous application of diamond-like carbon coating and surface amination on polyether ether ketone: Towards superior mechanical performance and osseointegration

Smart Materials in Medicine, 2021
Poor osseointegration ability and the release of worn debris after implantation are the main issues impeding the clinic application of polyether ether ketone (PEEK) as orthopedics.
Shi Mo, Feilong Zhao, Ang Gao, Yuzheng Wu, Qing Liao, Lingxia Xie, Haobo Pan, Liping Tong, Paul K. Chu, Huaiyu Wang   +9 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Glucocorticoid‐induced osteonecrosis in systemic lupus erythematosus patients

Clinical and Translational Medicine, 2021
Osteonecrosis (ON) is a complex and multifactorial complication of systemic lupus erythematosus (SLE). ON is a devastating condition that causes severe pain and compromises the quality of life.
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung‐Hyun Park‐Min   +5 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Genetic Epidemiology of Age-Related Macular Degeneration (AMD): The Role of the Complement Component 2 (C2) and Complement Factor B (CFB) Genes in Determining AMD Subphenotypes [PDF]

, 2009
Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in people over the age of 50 in the developed world. Inflammation has a central role in the pathobiology of AMD; complement pathway dysfunction is thought to induce
Longville, Brooke Allison Cattell
core