Results 131 to 140 of about 2,374,007 (316)
Land degradation: links to agricultural output and profitability
To understand land degradation and assess policy responses, knowledge is needed of the bio-physical causes, the economic effects on farms and the incentives farmers face to avoid or ameliorate the degradation.
Gretton, Paul, Salma, Umme
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
reservedThis thesis addresses the degradation mechanisms of quantum-dot lasers for silicon photonics by means of two different experiments. The first one had the goal of determining how different types of doping schemes, including beryllium, carbon, and ...
MURARO, EDOARDO
core
Ube2m-Mediated P27kip1 Degradation in Gemcitabine Cytotoxicity
, 2012 Gemcitabine 2-deoxy-2, 2-difluorocytidine; Gem is a nucleoside anti- metabolite and is commonly used for treating various human cancers including human bladder carcinoma. Gemcitabine not only functions as a suicide nucleoside analog but also inhibits DNA
黃阿梅;高毓婷;林秉毅;周季賢;胡惠婷;劉界元;侯自銓;蒲永孝 +1 more
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression
Cellular & Molecular Biology LettersBackground The incidence of atherosclerosis markedly rises following menopause. Our previous findings demonstrated that elevated follicle-stimulating hormone (FSH) levels in postmenopausal women accelerate atherosclerosis progression. Plaque instability,
Ping Li +8 more
doaj +1 more source
Handbook of Environmental Degradation of Materials
, 2012 Nothing stays the same for ever. The environmental degradation and corrosion of materials is inevitable and affects most aspects of life. In industrial settings, this inescapable fact has very significant financial, safety and environmental implications.
Kutz, Myer
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source