Results 41 to 50 of about 4,101,114 (282)

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Nature Communications
The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular glues) in clinical development. Biophysical and structural investigation of
Alena Kroupova, Valentina A. Spiteri, Zoe J. Rutter, Hirotake Furihata, Darren Darren, Sarath Ramachandran, Sohini Chakraborti, Kevin Haubrich, Julie Pethe, Denzel Gonzales, Andre J. Wijaya, Maria Rodriguez-Rios, Manon Sturbaut, Dylan M. Lynch, William Farnaby, Mark A. Nakasone, David Zollman, Alessio Ciulli   +17 more
doaj   +1 more source

Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma

BMC Cancer, 2019
Background Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression.
Mei-Mei Li, Yun-Qiang Tang, Yuan-Feng Gong, Wei Cheng, Hao-Long Li, Fan-En Kong, Wen-Jie Zhu, Shan-Shan Liu, Li Huang, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu   +11 more
doaj   +1 more source

Facile Preparation of Cu2+-doped Tin(IV) Pyrophosphate /Potassium Metaphosphate Composite as a Highly Efficient Electrolyte for Intermediate Temperature SOFCs

International Journal of Electrochemical Science, 2020
In this study, a Sn0.95Cu0.05P2O7/KPO3 composite ceramic was synthesized via a facile solid state reaction method and characterized by X-ray diffractometer (XRD), scanning electron microscopy (SEM) and Raman spectroscopy.
RuijuanShi, Jingjing Zhu, Peng Sun, Nan Wang, Junlong Liu, Hongtao Wang   +5 more
doaj   +1 more source

Degradation of Amylin by Insulin-degrading Enzyme [PDF]

Journal of Biological Chemistry, 2000
A pathological feature of Type 2 diabetes is deposits in the pancreatic islets primarily composed of amylin (islet amyloid polypeptide). Although much attention has been paid to the expression and secretion of amylin, little is known about the enzymes involved in amylin turnover.
R G, Bennett, W C, Duckworth, F G, Hamel
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Effect of microwave treatment on tensile properties of sugar palm fibre reinforced thermoplastic polyurethane composites

Defence Technology, 2018
The effect of microwave treatment on the tensile properties of treated sugar palm fibre with 6% NaOH reinforced thermoplastic polyurethane composites was investigated. Firstly, the sugar palm fibres were treated by 6% alkali solution.
A.A. Mohammed, D. Bachtiar, M.R.M. Rejab, J.P. Siregar   +3 more
doaj   +1 more source

UV Degradation of the Optical Properties of Acrylic for Neutrino and Dark Matter Experiments [PDF]

, 2009
UV-transmitting (UVT) acrylic is a commonly used light-propagating material in neutrino and dark matter detectors as it has low intrinsic radioactivity and exhibits low absorption in the detectors' light producing regions, from 350 nm to 500 nm ...
, , , , , A.R. Mahoney, ASTM Standard, B Littlejohn, B. Ranby, Daya-Bay collaboration, Double CHOOZ collaboration, E Gettrust, J.D. Stachiw, K M Heeger, M Lyman, M.G. Boulay, T Wise   +16 more
core   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Degradation effects in sc-Si PV modules subjected to natural and induced ageing after several years of field operation [PDF]

, 2012
This paper presents ageing effects observed in sc-Si PV modules operating in field conditions for 18 and over 22 years. The effects of both natural ageing processes and induced ageing by external agents, causing partial or total shading of cells for a ...
Kaplani, E.
core