Results 41 to 50 of about 1,819,363 (295)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Genetic and Biochemical Characterization of 2-Chloro-5-Nitrophenol Degradation in a Newly Isolated Bacterium, Cupriavidus sp. Strain CNP-8

Frontiers in Microbiology, 2017
Compound 2-chloro-5-nitrophenol (2C5NP) is a typical chlorinated nitroaromatic pollutant. To date, the bacteria with the ability to degrade 2C5NP are rare, and the molecular mechanism of 2C5NP degradation remains unknown.
Jun Min, Weiwei Chen, Jinpei Wang, Xiaoke Hu   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Degradation transformations in topologically disordered solids: 4. Features of exponential kinetics

Технологія та конструювання в електронній апаратурі, 2005
The manifestations of exponential degradation kinetics in topologically disordered materials are analyzed. Degradation transformations are determined by a single prevailing activation energy value, regardless of the structural dispersity of the system ...
V. A. Balitskaya, I. M. Brunets, М. M. Vakiv, G. I. Klim, O. I. Shpotyuk   +4 more
doaj  

Passage and degradation kinetics of solid particles from agricultural residues

Semina: Ciências Agrárias
The use of waste generated in the agroindustry can result in increased production at a relatively low cost compared to traditional ingredients, especially for producers with easy access to this waste.
Marco Aurélio Teixeira Andrade, Bruna Cardoso Braga, Severino Delmar Junqueira Villela, Raphael dos Santos Gomes, Maria Eduarda Lara Resende, Guilherme Campos Leitão, Fernando de Paula Leonel   +6 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Degradation kinetics of biodegradable chitosan, polyvinyl alcohol, and zinc oxide hydrogel for the amoxicillin drug delivery application

Next Materials
Biodegradable polymer hydrogels and scaffolds are the prime requirements in surgical associate applications. This helps in self-degradation of the polymer hydrogel over time and a further surgery is not required which saves the patient from surgical ...
Samriti G. V, H. Premkumar, Vinay Kumar
doaj   +1 more source

Cinética de remoção de matéria orgânica em sistemas alagados construídos cultivados com lírio amarelo Organic matter removal kinetics in constructed wetlands cultivated with yellow lily

Revista Brasileira de Engenharia Agrícola e Ambiental, 2011
Objetivou-se, com a realização deste trabalho, obter o ajuste do modelo matemático adaptado de cinética de primeira ordem e os respectivos parâmetros cinéticos para descrição da degradação da matéria orgânica em SACs cultivados com lírio amarelo ...
Renata C. Chagas, Antonio T. de Matos, Paulo R. Cecon, Paola A. V. Lo Monaco, Luis G. F. França   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source