Results 61 to 70 of about 1,819,363 (295)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The Photocatalytic, Thermal Degradation Kinetics and Lifetime Prediction of Some Commercial Reactive Dyes [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2017
The photocatalytic degradation of the commercial reactive Black5 (RB5), Blue19 (RB19), Green19 (RG19), Red120 (RR120), and Yellow81 (RY81) in aqueous solution and sunlight were examined in the presence of Fe2O3 and the mixture Fe2O3/H2O2 as catalysts ...
Hussein Al-Maydama, Mohamed S. Al Kahali, Adlia A. Abduljabbar, Abdulbasset M. Aaad   +3 more
doaj  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Carotenoid stability in grains of maize hybrids compared to complete feeds for laying hens following preparation and storage

Applied Food Research
Yellow maize grain is an important source of carotenoids for yolk pigmentation, but carotenoids are susceptible to degradation during storage of feeds for laying hens.
Dora Zurak, Veronika Gunjević, Zlatko Svečnjak, Goran Kiš, Darko Grbeša, Kristina Kljak   +5 more
doaj   +1 more source

Degradation of contaminated plastics: a kinetic study

Polymer Degradation and Stability, 1995
The thermal degradation of polypropylene (PP), polyacrylonitrile butadiene styrene (ABS), polyurethane (PU) and polyvinyl chloride (PVC) have been studied in the presence of copper, iron oxide and dirt. The rate constants and kinetic parameters for the degradation processes have been measured using the variable heating rate isoconversion method.
Day, M., Cooney, J. D., MacKinnon, M.
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Use of Factorial Designs to Reduce Stability Studies for Parenteral Drug Products: Determination of Factor Effects via Accelerated Stability Data Analysis

Pharmaceutics
Objectives: This study explores the potential of factorial analysis as an alternative strategy for optimizing stability study designs for registration batches—an approach not currently addressed in ICH Q1D, which focuses solely on bracketing and ...
Lara Pavčnik, Simona Bohanec, Tina Trdan Lušin, Robert Roškar   +3 more
doaj   +1 more source