Results 51 to 60 of about 7,051,446 (291)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Isolation and identification of naturally occurring textile effluent-degrading bacteria and evaluation of their ability to inhibit potentially toxic elements

Results in Engineering, 2023
Untreated textile dye-contaminated wastewater contains potentially toxic elements (PTEs) and causes pollution when discharged. Herein, we attempted to isolate and identify naturally occurring effluent-degrading bacteria and investigate their resistance ...
Suman Barua, Sohag Miah, M. Nuruddin Mahmud, Ismail M.M. Rahman   +3 more
doaj   +1 more source

Molecular glue degrader for tumor treatment

Frontiers in Oncology
Targeted Protein Degradation (TPD) represented by Proteolysis-Targeting Chimeras (PROTAC) is the frontier field in the research and development of antitumor therapy, in which oral drug HP518 Receives FDA Proceed Authorization for its IND Application for Prostate Cancer Treatment.
Yuhan Hu, Yan Yan, Jiehao Wang, Jiangxue Hou, Quande Lin   +4 more
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of bacterial strains capable of degrading Malaysian petroleum sludge [PDF]

, 2009
In an organic sludge biodegradation process, identification of bacterial strains with effective biodegradation capabilities indigenous to the sludge is an important step as isolation and subsequent usage of such strains can enhance the rate of the ...
Dzulkapli, N.F., Kalavathy, R., Abdul-Talib, S., Yin, C-Y   +3 more
core  

Obstacles to torture rehabilitation at Guantánamo Bay

Torture, 2017
This article sets out the legal duty of the United States of America to provide victims of torture and cruel, inhumane and degrading treatment (CIDT) the right to full rehabilitation under international law, including those still detained at the facility
James Connell, Alka Pradhan, Margaux Lander   +2 more
doaj   +1 more source

Degradation of diazinon in apple juice by ultrasonic treatment

Ultrasonics Sonochemistry, 2010
The degradation of diazinon spiked in apple juice treated by ultrasonic treatment was investigated in this paper. Results showed that the ultrasonic power and initial concentration of diazinon significantly influenced the degradation percentage of diazinon ...
Yuanyuan, Zhang, Wenjia, Zhang, Xiaojun, Liao, Jianing, Zhang, Yaxi, Hou, Zhiyong, Xiao, Fang, Chen, Xiaosong, Hu   +7 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source