Results 121 to 130 of about 63,047 (307)

Elevated blood histamine levels and mast cell degranulation in solar urticaria. [PDF]

, 1980
JL Hawk, RA Eady, A.V.J. CHALLONER, A. KOBZA-BLACK, T KEAHEY, M.W. Greaves   +5 more
openalex   +1 more source

Modulation of neutrophil degranulation by hypoxia

, 2015
Neutrophils are key effector cells of the innate immune system. They employ a number of powerful ‘weapons’ to eliminate pathogens, including an array of destructive proteins packaged into distinctive granule subsets. In addition to their microbicidal activity, these granule proteins are capable of causing substantial tissue damage if inappropriately ...
openaire   +2 more sources

Targeting SHP‐1‐Mediated Inhibition of STAT3 and ERK Signalling Pathways Rescues the Hyporesponsiveness of MHC‐I‐Deficient NK‐92MI

Cell Proliferation, EarlyView.
B2M knockout (KO) represents a crucial strategy for generating universal NK‐92MI cell products. This approach results in increased phosphorylation of SHP‐1 and inhibited phosphorylation of STAT3 and ERK, which ultimately affect their cytotoxic capabilities. SHP‐1 KO facilitates the restoration of cytotoxic function in B2M KO NK‐92MI cells.
Kuo Yu, Xiaolong Liu, Guangyuan Wu, Zhongyao An, Xin Wang, Yang Liu, Hailong Wang, Mingli Huang, Linlin Zhao, Ce Shi, Xin Sun, Lu Xu, Sen Qi, Xin Zhang, Yueqiu Teng, Song Guo Zheng, Zhiren Zhang, Zhenkun Wang   +17 more
wiley   +1 more source

Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation.

, 1977
David M. Segal, Joel D. Taurog, H Metzger   +2 more
openalex   +1 more source

Aging Increases the Severity of Anaphylaxis Through Changes in Mast Cell Numbers and Histamine Sensitivity

Allergy, EarlyView.
Jasper B. J. Kamphuis, Alexia Loste, William P. M. Worrall, Nadine Serhan, Thomas Villeneuve, Pol André Apoil, Benjamin Trouche‐Estival, the IHU HealthAge INSPIRE/Open Science group, Catherine Takeda, Catherine Faisant, Françoise Lala, Gabor Abellan Van Kan, Zara Steinmeyer, Antoine Piau, Tony Macaron, Davide Angioni, Pierre‐Jean Ousset, Laurent Guilleminault, Nicolas Gaudenzio, Laurent L. Reber   +19 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Hemocytes: Central drivers of antimicrobial peptide expression and immune proteins in both cellular and humoral responses of Galleria mellonella

Entomologia Experimentalis et Applicata, EarlyView.
We assessed gallerimycin, galiomycin, and hemolin gene expression in Galleria mellonella whole larvae, hemocytes, and fat body at 4 and 24 h post‐injection of Candida albicans and silica beads. Higher gallerimycin and galiomycin expression in hemocytes signified their role in antimicrobial peptide synthesis.
Serhat Kaya, Tülay Turgut Genç, Melih Günay   +2 more
wiley   +1 more source

Protective effects of neutrophil serine protease inhibition against ischemia–reperfusion injury in lung or heart transplantation

The FEBS Journal, EarlyView.
A major complication of organ transplantation is primary graft dysfunction, which represents the leading cause of early post‐transplantation morbidity and mortality. Pre‐operative depletion of neutrophil serine proteases in circulating neutrophils by pretreatment with a cathepsin C inhibitor in recipients could prevent early post‐operative ...
Sevil Korkmaz‐Icöz, Gábor Szabó, Artur Gieldon, Patrick P. McDonald, Alexey Dashkevich, Ali Önder Yildirim, Brice Korkmaz   +6 more
wiley   +1 more source

Human mast cells synthesize new granules during recovery from degranulation. In vitro studies with mast cells purified from human lungs [PDF]

, 1988
Dvorak Am, RP Schleimer, LM Lichtenstein
openalex   +1 more source

Melanoma cells suppress mast cell function via a melanin‐dependent mechanism

The FEBS Journal, EarlyView.
Mast cells are frequently found in melanoma tumors, and here we investigated whether melanoma cells can influence mast cell function. Our study reveals that melanin, secreted from melanoma cells, is taken up by mast cells and can reach the mast cell nucleus.
Fábio Rabelo Melo, Lea Nyman, Ida Österman Menander, Mirjana Grujic, Gunnar Pejler   +4 more
wiley   +1 more source