Results 121 to 130 of about 137,298 (386)

Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells [PDF]

, 2018
The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the
Ambrosio, Laura Fernanda, Celias, Daiana Pamela, Cervi, Laura Alejandra, Chiapello, Laura Silvina, Motran, Claudia Cristina, Silvane, Leonardo Micael, Theumer, Martín Gustavo, Volpini, Ximena   +7 more
core   +1 more source

Cell Surface-Anchored Fluorescent Probe Capable of Real-Time Imaging of Single Mast Cell Degranulation Based on Histamine-Induced Coordination Displacement.

Analytical Chemistry, 2016
Mast cells secrete histamine upon degranulation triggered by various stimuli. Herein, we report the new detection method of mast cell degranulation using the fluorescent probe capable of detection of the released histamine.
Yuji Oshikawa, K. Furuta, Satoshi Tanaka, A. Ojida   +3 more
semanticscholar   +1 more source

Epidermal Interferon‐κ Drives Cutaneous Lupus‐Like Lesions, Photosensitivity, and Systemic Autoimmunity In Vivo

Arthritis &Rheumatology, EarlyView.
Objective Keratinocyte‐derived interferon (IFN) κ is chronically overexpressed in human nonlesional systemic lupus erythematosus (SLE) skin. Recent evidence suggests that epidermal signals instruct the immune system in SLE, but whether epidermal IFNκ alone is sufficient to drive lupus phenotypes has not been investigated.
Benjamin Klein, Deborah J. Colesa, Yiqing Gao, Patrick A. O'Brien, Lin Zhang, Lori Lowe, Kelsey E. McNeely, Nguyen Thi Kim Nguyen, Svenja Henning, Mehrnaz Gharaee‐Kermani, Jeffrey B. Hodgin, Jacob W. S. Martens, Johann E. Gudjonsson, Celine C. Berthier, J. Michelle Kahlenberg   +14 more
wiley   +1 more source

Unconjugated Bile Acids and Alcohols Inhibit Degranulation of Stimulated RBL-2H3 Cells

Frontiers in Bioscience-Landmark
Background: Steroid hormones are widely used as anti-allergic drugs because of their potent anti-inflammatory properties and ability to suppress histamine release by 60–80%.
Michiko Yoshii, Ai Tarao, Yasuko Ichinose, Naomi Iwasa, Fumi Tanaka, Yuhki Yanase, Koichiro Ozawa   +6 more
doaj   +1 more source

Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37

Scientific Reports, 2016
Mast cell degranulation is regulated by the small guanosine triphosphatases (GTPases) Rab27a and Rab27b, which have distinct and opposing roles: Rab27b acts as a positive regulator through its effector protein Munc13-4, a non-neuronal isoform of the ...
H. Higashio, Y. Satoh, T. Saino
semanticscholar   +1 more source

Comparative Efficacy and Safety of Anakinra and Canakinumab in Patients With VEXAS Syndrome: An International Multicenter Study

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to compare differences in clinical response, drug survival, and adverse event rates between anakinra and canakinumab in VEXAS (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic) syndrome. Methods This multicenter international study includes patients with VEXAS from France, Israel, and Italy treated with ...
Tali Eviatar, Dafne Capelusnik, Corrado Campochiaro, Valentin Lacombe, Vincent Jachiet, Michael Zisapel, Iftach Sagy, Oshrat E. Tayer‐Shifman, David Ozeri, Shaye Kivity, Alessandro Tomelleri, Benjamin Terrier, Hagit Peleg, Thibault Comont, Karim Sacre, Pascal Woaye‐Hune, Laurent Arnaud, Estibaliz Lazaro, Vincent Grobost, Francois Lifermann, Maxime Samson, Samuel Ardois, Alice Garnier, Alexandre Maria, Alain Cantagrel, Aurore Meyer, Jean‐David Bouaziz, Mael Heiblig, Lorenzo Dagna, Elisa Diral, Olivier Kosmider, Ori Elkayam, Jérôme Hadjadj, Sophie Georgin‐Lavialle, Olivier Fain, Arsene Mekinian   +35 more
wiley   +1 more source

Spatial Eosinophil Phenotypes as Immunopathogenic Determinants in Inflammatory Diseases

Cells
Eosinophils are increasingly recognized as adaptable immune cells that exhibit diverse phenotypes and effector functions across different tissues and disease states.
Jonas S. Erjefält
doaj   +1 more source

Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils [PDF]

, 2010
Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides.
Arts, I.C.W., Bartholomé, R., Bast, A., Dagnelie, P.C., Haenen, G., Hollman, P.C.H., Keijer, J., Kroon, P.A., Needs, P.W., Roos, D.   +9 more
core   +2 more sources

The antinociception of oxytocin on colonic hypersensitivity in rats was mediated by inhibition of mast cell degranulation via Ca2+-NOS pathway

Scientific Reports, 2016
This study was conducted to investigate the effects of oxytocin (OT) on visceral hypersensitivity/pain and mast cell degranulation and the underlying mechanisms. We found that oxytocin receptor (OTR) was expressed in colonic mast cells in humans and rats,
L. Gong, Jing Li, Yan Tang, T. Han, Chuanfei Wei, Xiao Yu, Jingxin Li, Rong Wang, Xuelian Ma, Kejing Liu, L. Geng, Shaozhuang Liu, Bing Yan, Chuanyong Liu   +13 more
semanticscholar   +1 more source

Evidence for eosinophil degranulation in acute appendicitis

Indian Journal of Pathology and Microbiology, 2008
Finding of increased numbers of eosinophils in the muscle in cases of acute appendicitis has led to the hypothesis that it may have an allergic origin. This study aimed to measure the eosinophil degranulation resulting in a rise in the serum of eosinophil granule proteins that would be expected in such cases.
Santosh G, Aravindan K
openaire   +3 more sources