Results 101 to 110 of about 87,250 (304)

Lipid droplet profiling during neutrophil differentiation by stimulated Raman scattering microscopy

Biotechnology Progress, EarlyView.
Abstract Lipid droplets (LDs) are dynamic organelles that serve as metabolic hubs and emerging regulators of immune cell fate. Although LDs have been implicated in immune regulation, how LD metabolism is remodeled during neutrophil differentiation and how stage‐specific LD dynamics shape mature neutrophil function remain poorly defined.
Ting‐Jung Sung, Bin Dong, Jingqiao Shen, Yan Tan, Chi Zhang, Xiaoping Bao   +5 more
wiley   +1 more source

Cutting Edge: Differential Regulation of Chemoattractant Receptor-Induced Degranulation and Chemokine Production by Receptor Phosphorylation [PDF]

, 2001
Phosphorylation of G protein-coupled receptors and the subsequent recruitment of β-arrestin play an important role in desensitization of receptor-mediated responses, including degranulation in leukocytes.
Ahamed, J., Haribabu, B., Ali, H.
core   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Role of female sex hormones, estradiol and progesterone, in mast cell behaviour

Frontiers in Immunology, 2012
Female sex hormones have long been suspected to have an effect on mast cell (MC) behaviour. This assumption is based on the expression of hormone receptors in MCs as well as on the fact that many MC-related pathophysiological alterations have a different
Oliver eZierau, Ana Claudia Zenclussen, Federico eJensen   +2 more
doaj   +1 more source

Allergen-specific degranulation of RBL cells.

, 2014
RBL cells were passively sensitized with undiluted serum pools of groups sensitized i.p. to unmodified gluten (A), enzymatic hydrolyzed gluten (B) or acid hydrolyzed gluten (C).
Stine Kroghsbo (560684), Charlotte B. Madsen (560688), Nanna B. Andersen (628065), Tina F. Rasmussen (628066), Susanne Jacobsen (628067)   +4 more
core   +1 more source

Temperature homeostasis disruption and hypothalamic alterations in experimental drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Objective Elevated body temperature may increase seizure risk, yet the relationship between thermoregulation and seizures, as well as the underlying mechanisms, remains poorly understood. We investigated whether thermoregulatory control is altered in experimental temporal lobe epilepsy (TLE), as such impairment could reduce the ability of ...
Rossella Di Sapia, Akash Bera, Omar Mamad, James D. Mills, Benjamin Villasana‐Salazar, Giada Lavigna, Edoardo Micotti, Manuela Conticello, Asmin Alam, Roberto Chiesa, Francesca Pagani, Roberta Frapolli, Angelo M. Lavecchia, Christodoulos Xinaris, Eleonora Aronica, Andre Altmann, Teresa Ravizza, Sanjay M. Sisodiya, David C. Henshall, Annamaria Vezzani   +19 more
wiley   +1 more source

Changes in neutrophil surface receptor expression, degranulation, and respiratory burst activity after moderate- and high-intensity exercise

, 2004
Intense exercise stimulates the systemic release of a variety of factors that alter neutrophil surface receptor expression and functional activity. These alterations may influence resistance to infection after intense exercise.
Wilson, Gary, Mackinnon, Laurel, Kazunori Nosaka, Laurel Mackinnon, Suzuki, Katsuhiko, Yamaya, Kanemitsu, Jonathan Peake, Matthew Hordern, Hordern, Matthew, Katsuhiko Suzuki, Mackinnon, Laurel T., Gary Wilson, Kanemitsu Yamaya, Nosaka, Kazunori, Jeff S. Coombes, Coombes, Jeff S., Peake, Jonathan M., Peake, Jonathan   +17 more
core   +1 more source

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Effects of Ampelopsis brevipedunculata on Ovalbumin-Induced Allergic Airway Inflammation via Regulating Mast Cell Activation and PLCγ/Akt/NF-κB Signaling Pathway

Molecules
Asthma is a chronic allergic airway inflammation that requires ongoing therapeutic intervention and reduces the patient’s quality of life. Therefore, safe and efficacious drugs for the treatment of asthma are urgently needed.
Yeon-Yong Kim, Hyun-Jae Jang, Seungwon Jeong, Seung Woong Lee, Sang-Hyun Kim, Soyoung Lee   +5 more
doaj   +1 more source

Lytic Granule Polarization, Rather than Degranulation, Is the Preferred Target of Inhibitory Receptors in NK Cells

, 2010
Natural cytotoxicity is achieved by polarized release of perforin and granzymes at the NK cell–target cell immunological synapse. Signals for granule polarization and degranulation can be uncoupled in NK cells, which raises the question of their ...
Eric O. Long, Asmita Das
core   +1 more source