Results 121 to 130 of about 87,250 (304)

Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation

, 2018
Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine ...
Xian-Cheng Jiang, Geraghty, Patrick, Dabo, Abdoulaye, Ochieng, Pius, Macarulay, Reane, Patrick Geraghty, Sridesh Nath, Edward Eden, Robert F. Foronjy, Reane Macarulay, Pius Ochieng, Foronjy, Robert F, Campos, Michael, Jiang, Xian-Cheng, Abdoulaye Dabo, Michael Campos, Nath, Sridesh, Ochieng, Pius, MD, Eden, Edward   +18 more
core   +2 more sources

Mechanisms of glyceryl trinitrate provoked mast cell degranulation

, 2015
BACKGROUND: Migraine patients develop attacks several hours after intravenous infusion of glyceryl trinitrate. Due to the short half-life of nitric oxide, this delayed migraine cannot be caused by a direct action of nitric oxide derived from glyceryl ...
Petersen, Steffen, Ramachandran, Roshni, Jansen-Olesen, Inger, Pedersen, Sara Hougaard, Amrutkar, Dipak Vasantrao, Olesen, Jes   +5 more
core   +1 more source

Precision immunomodulation for pediatric hemophagocytic lymphohistiocytosis in intensive care

Pediatric Investigation, EarlyView.
This review presents a bedside framework for recognizing pediatric hemophagocytic lymphohistiocytosis and cytokine storm, stabilizing organ dysfunction, identifying the underlying phenotype, selecting targeted immunomodulation, considering extracorporeal adjuncts, and reassessing response within 24–72 h. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH)
Weerapong Lilitwat, Prakreeti Bhandari
wiley   +1 more source

Regulation of goblet cell degranulation in isolated pancreatic ducts

, 1995
Neurohumoral control of goblet cell degranulation in isolated segments of the guinea pig main pancreatic duct was examined using morphometric procedures.
S. R. Hootman, J. de Ondarza
core   +1 more source

Allergen‐Functionalized Microfluidic Immunoadsorption Platform for Selective Depletion of Peanut‐Specific Antibodies From Whole Blood

Journal of Polymer Science, EarlyView.
We present a microfluidic immunoadsorption platform functionalized with a layer‐by‐layer (LbL) nanofilm composed of poly(diallyldimethylammonium chloride) (PDDA) and protein extract (PE) for selective capture of peanut‐specific antibodies directly from the whole blood obtained from a peanut allergy mouse model.
Hesaneh Ahmadi, Nur Hendri Wahyu Firdaus, Rutwik Joshi, Akhilesh Kumar Shakya, Wei Li   +4 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

NK-1 antagonist CP99994 inhibits stress-induced mast cell degranulation in rats

, 2004
Mast cells are implicated in stress-induced inflammatory skin diseases such as psoriasis. Mechanisms of stress-induced mast cell degranulation however, are not entirely clear.
AKICI, AHMET, ERCAN, FERİHA
core   +1 more source

Potential of Ginkgo biloba Extract to Intervene in Chronic Inflammation‐Related Diseases

Phytotherapy Research, EarlyView.
Chronic inflammation is a pathological mechanism underpinning many diseases. Ginkgo biloba extract (GBE) is well known for its anti‐inflammatory property. GBE and its active constituents have been shown to attenuate pro‐inflammatory cytokine production, suppress nuclear factor kappa B activation, restore redox homeostasis, and modulate disease‐relevant
Yipeng Lin, Inho Cho, Xue Zhu, Ke Wang, Ling Zhu, Wenchang Wong, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source

Degranulation of rat omental mast cells by A1 receptor agonists in vitro

, 1996
The haemodynamic effects of adenosine are thought to result in part from a release of mast cell amines via A3 receptor stimulation. To investigate the nature of the receptors involved in adenosine-induced mast cell degranulation in the rat isolated ...
A. M. Northover, B. J. Northover
core   +1 more source