Results 91 to 100 of about 87,250 (304)

Fungus-induced inflammation and eosinophil degranulation

open access: yes, 2009
This document relates to methods and materials involved in fungus-induced inflammation and eosinophil degranulation. For example, isolated nucleic acids encoding fungal polypeptides, fungal polypeptides, methods for assessing fungus-induced inflammation,

core  

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia

open access: yesFrontiers in Cellular and Infection Microbiology
SARS-CoV-2–induced excessive inflammation in brain leads to damage of blood–brain barrier, hypoxic-ischemic injury, and neuron degeneration. The production of inflammatory cytokines by brain microvascular endothelial cells and microglia is reported to be
Meng-Li Wu   +8 more
doaj   +1 more source

Ang-1 suppressed compound 48/80 induced mast cells degranulation.

open access: yes, 2014
Degranulation was determined by staining with dyes and measuring the release of histamine and tryptase. A: Mast cells degranulation was observed by microscope 20 min after compound 48/80 10 µg/mL treatment.
Yi-Nan Liu (524291)   +6 more
core   +1 more source

Ileal granulocyte degranulation for experiments 1–3.

open access: yes, 2023
All chicks received in ovo inoculations on ed18 consisting of saline or 102 cells of C. freundii or LAB inoculums. On day of hatch (Exp. 3 only) and d10, ileal segments were collected to assess ileal granulocyte degranulation via β-D-glucuronidase ...
Michael Trombetta (16699179)   +4 more
core   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

open access: yesBiotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga   +2 more
wiley   +1 more source

Natural killer cell degranulation and lytic proteins in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

open access: yes, 2014
Objectives: Reduced Natural Killer (NK) cell cytotoxic activity is a recurring finding in patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME).
Staines, Don   +6 more
core  

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

open access: yesBMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma   +8 more
wiley   +1 more source

Unconjugated Bile Acids and Alcohols Inhibit Degranulation of Stimulated RBL-2H3 Cells

open access: yesFrontiers in Bioscience-Landmark
Background: Steroid hormones are widely used as anti-allergic drugs because of their potent anti-inflammatory properties and ability to suppress histamine release by 60–80%.
Michiko Yoshii   +6 more
doaj   +1 more source

Inhibitory effects of pemirolast potassium and FK506 on degranulation and IL-8 production of eosinophils

open access: yesAllergology International, 1999
Eosinophils are the key effector cells for allergic inflammation. In order to clarify drugs which can regulate eosinophil function, we investigated the direct effect of pemirolast potassium (anti-allergic drug) and FK506 (immunosupressant) on eosinophil ...
Naomi Yamashita   +7 more
doaj   +1 more source

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