Results 271 to 280 of about 63,047 (307)

Effects of Mast-Cell Degranulation on the Choroid

Archives of Ophthalmology, 1966
The mast cells have been an object of study since they were first described by Ehrlich in 1879. Although there is variation among species, these cells have been seen most commonly along blood vessels, in organ capsules, and floating free in the peritoneal cavity. They are generally associated with the connective tissue, are abundant in skin, and scarce
Richard S. Smith, Stephen L. Trokel
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Degranulation mechanisms in human leukemic basophils

Clinical Immunology and Immunopathology, 1976
Abstract The peripheral blood basophils of a patient with chronic myelogenous leukemia, basophilic phase (up to 85% of circulating leukocytes were mature basophils), and substantially elevated levels of urine histamine were studied in the electron microscope in an attempt to relate morphologic changes to possible mechanisms of mediator secretion.
Dickersin Gr, Carey Rw, Anne B. Connell, Harold F. Dvorak, Ann M. Dvorak   +4 more
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Stimulation of Human Neutrophil Degranulation by Mefloquine

International Archives of Allergy and Immunology, 1988
The effect of the antimalarial drug mefloquine on human neutrophil degranulation, chemiluminescence, superoxide production and viability was examined in vitro. Mefloquine was found to significantly stimulate the release of lysozyme, β-glucuronidase and myeloperoxide at a concentration of 10 μg/ml (2.5 × 10^––5<i>M</i>)
Anthony W. Ferrante, E. J. Bates
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Granulation-Degranulation Processes

2020
In this chapter, we discuss the concept of information granulation and degranulation as one of the fundamental computing paradigms of Granular Computing supporting interaction with real-world environment. In the setting of fuzzy sets, the wording fuzzification-defuzzification is commonly used.
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Neutrophil Degranulation of Azurophil and Specific Granules

2019
Neutrophils play a pivotal role in innate immunity and in the inflammatory reactions. Upon activation, neutrophils release several toxic molecules directed against microbial pathogens into the phagosome. These molecules include reactive oxygen species (ROS), myeloperoxidase, glucosidases, proteases, and antibacterial peptides.
Bedouhene, Samia, Dang, Pham My-Chan, Hurtado-Nedelec, Margarita, El-Benna, Jamel   +3 more
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Endotoxin-induced degranulation of the amebocyte

Experimental Cell Research, 1982
Abstract Exocytosis and gelation of the granule contents of the amebocyte of Limulus polyphemus have been studied in a perfusion chamber observed with Nomarski differential interference contrast microscopy. Degranulation in response to bacterial endotoxin or the ionophore A23187 was significantly inhibited by the anion channel blocking agents suramin,
Peter B. Armstrong, Peter B. Armstrong, Frederick R. Rickles, Frederick R. Rickles   +3 more
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Neutrophil degranulation: coactivation of chemokine receptor(s) is required for extracellular nucleotide-induced neutrophil degranulation

Medical Hypotheses, 2001
Extracellular nucleotide-induced stimulation of leukocytes and subsequent adhesion to endothelium plays a critical role in inflammatory diseases. The extracellular nucleotides stimulate a P2Y receptor on human PMN with the pharmacological profile of the P2Y2 receptor.
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Degranulation and Intracellular Killing of Bacteria [PDF]

, 1976
Metchnikoff knew that neutrophils possessed “ferments” capable of digesting gelatin and other proteins, and that phagocytosed grains of litmus sometimes turned red. He knew that organisms taken up by neutrophils were enclosed in vacuoles and not admitted to the cytoplasm proper, and that in the vacuoles they were slowly digested.
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Leukocyte(s) degranulation: therapeutic targets in [NTP]O and [NDP]O mediated leukocyte(s) degranulation

Medical Hypotheses, 2004
Extracellular nucleotide-induced stimulation and activation of peripheral blood leukocyte(s) and subsequent degranulation plays a critical role in immediate type hypersensitivity reaction and other inflammatory diseases. The extracellular nucleotides [NTP]O stimulate a P2Y receptor(s) on human PMN with the pharmacological profile similar to that of the
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Specific degranulation of human polymorphonuclear leukocytes

Nature, 1974
THE human polymorphonuclear leukocyte (PMN) contains two types of cytoplasmic granules, specific or heterophil granules and azurophil granules1. These granules contain enzymes and various non-enzymatic proteins. The specific granule contains alkaline phosphatase and most of the lysozyme of the cell while the azurophil granule contains the acid ...
Beulah Holmes, James G. White, Richard D. Estensen   +2 more
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