Results 111 to 120 of about 4,835,163 (282)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
1-Generic degrees and minimal degrees in higher recursion theory
Japanese journal of mathematics. New series, 1986 The main result of the paper is that for many \(\Sigma_ 2\) inadmissible ordinals, no 1-generic degree bounds a minimal degree. A short description of the current state of study of the structure of 1-degrees in higher recursion theory is also included.
openaire +4 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Edge Degree Weight of Sequential Join of Graphs
Science Journal of University of Zakho, 2013 Let the weight w of an edge e= uv={u,v} of a graph G be defined by w(e)=deg(u)+deg(v)-2 and the weight of G be defined by w(G)= ∑ e ∈ E(G)w(e), where E(G) is the edge set of G.
Khidir R. Sharaf, Didar A. Ali
doaj
Fractional stochastic differential equations and degree theory: a unified perspective
Boundary Value ProblemsThis research focuses on the existence and uniqueness of solutions for a novel class of tempered φ-Caputo stochastic fractional differential equations.
M. Latha Maheswari +2 more
doaj +1 more source
A theory of degrees in education
HeliyonDegrees are presumably the most important institution in education markets. However, despite their high relevance, degrees and their design features remain poorly understood within the economics of education. This study addresses this gap. We provide an accurate formal definition of what constitutes a degree and formulate the first theory of degree ...
Stefan Winter +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Degree theory for the sum of VMO maps and maximal monotone maps
Cubo, 2011 Let be an open bounded domain, a VMO map, and T : D(T) a maximal monotone map wit . We construct a degree for the sum of f + T, which can be viewed as a generalization of the degree both for VMO maps and maximal monotone maps.Sea un dominio abierto, un ...
Yuqing Chen +2 more
doaj
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source