Results 91 to 100 of about 4,846,700 (284)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Existence of three solutions for a higher-order boundary-value problem
Electronic Journal of Differential Equations, 2009 We consider a higher-order multi-point boundary-value problem with a nonlinear boundary condition. Sufficient conditions are obtained for the existence of three solutions.
John R. Graef, Lingju Kong, Qingkai Kong
doaj
Effective Degree Theory on Multiplex Networks for Concurrent Three-State Spreading Dynamics
IEEE Access, 2019 We propose a model of concurrent three-state spreading dynamics on multiplex networks to study the co-evolution process of epidemic spreading and information diffusion.
Yinzuo Zhou, Cong Teng, Jie Zhou
doaj +1 more source
Tabular degrees in \Ga-recursion theory
Annals of Pure and Applied Logic, 1992 This paper develops the foundations of a theory of truth-table reducibilities in the setting of \(\alpha\)-recursion. A generalization of \(tt\)-reducibility and several generalizations of weak-\(tt\)-reducibility are given and their properties explored. Most of the main results deal with regular sets. For example, for each of the reducibilities given,
Bailey, Colin, Downey, Rod
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Boundary-value problems for nonautonomous nonlinear systems on the half-line
Electronic Journal of Differential Equations, 2011 A method is presented for proving the existence of solutions for boundary-value problems on the half line. The problems under study are nonlinear, nonautonomous systems of ODEs with the possibility of some prescribed value at $t=0$ and with the ...
Jason R. Morris
doaj
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Electronic Journal of Differential Equations, 2009 In this article, we consider the singular nonlinear elliptic problem $$displaylines{ -Delta u = g(u)+h( abla u)+f(u) quadhbox{in }Omega, cr u = 0 quadhbox{on }partialOmega.
Carlos C. Aranda
doaj