Results 71 to 80 of about 609,806 (243)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Approximate controllability and regularity for nonlinear differential equations
Advances in Difference Equations, 2011 In this article, we deal with the existence, uniqueness, and a variation of solutions of the nonlinear control system with nonlinear monotone hemicontinuous and coercive operator.
Kim Jin-Ran, Jeong Jin-Mun, Ju Eun-Young
doaj
A Conjecture Regarding the Extremal Values of Graph Entropy Based on Degree Powers
Entropy, 2016 Many graph invariants have been used for the construction of entropy-based measures to characterize the structure of complex networks. The starting point has been always based on assigning a probability distribution to a network when using Shannon’s ...
Kinkar Chandra Das, Matthias Dehmer
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
A degree theory for a class of perturbed Fredholm maps II
Fixed Point Theory and Applications, 2006 In a recent paper we gave a notion of degree for a class of perturbations of nonlinear Fredholm maps of index zero between real infinite dimensional Banach spaces.
Calamai Alessandro +2 more
doaj +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Effective Degree Theory on Multiplex Networks for Concurrent Three-State Spreading Dynamics
IEEE Access, 2019 We propose a model of concurrent three-state spreading dynamics on multiplex networks to study the co-evolution process of epidemic spreading and information diffusion.
Yinzuo Zhou, Cong Teng, Jie Zhou
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Existence of three solutions for a higher-order boundary-value problem
Electronic Journal of Differential Equations, 2009 We consider a higher-order multi-point boundary-value problem with a nonlinear boundary condition. Sufficient conditions are obtained for the existence of three solutions.
John R. Graef, Lingju Kong, Qingkai Kong
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source