Results 71 to 80 of about 4,846,700 (284)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Coexistence of steady state for a diffusive prey-predator model with harvesting

open access: yesElectronic Journal of Differential Equations, 2016
In this article, we study a diffusive prey-predator model with modified Leslie-Gower term and Michaelis-Menten type prey harvesting, subject to homogeneous Dirichlet boundary conditions.
Yan Li
doaj  

Ramanujan Complexes and bounded degree topological expanders

open access: yes, 2014
Expander graphs have been a focus of attention in computer science in the last four decades. In recent years a high dimensional theory of expanders is emerging. There are several possible generalizations of the theory of expansion to simplicial complexes,
Kaufman, Tali   +2 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Cross-World Comparatives for Modal Realists [PDF]

open access: yes, 2018
Divers (2014) argues that a Lewisian theory of modality which includes both counterpart theory and modal realism cannot account for the truth of certain intuitively true modal sentences involving cross-world comparatives.
Michels, Robert
core  

Degree Theory Beyond Continuous Maps [PDF]

open access: yes, 1996
The author gives an introductory overview (without proofs) on recent extensions of finite-dimensional degree theory to the non-continuous case. This is of particular interest in dealing with the Ginzburg-Landau equations. Let \(X,Y\) be compact connected Riemannian manifolds of the same dimension with \(Y\) smoothly embedded in some \(\mathbb{R}^{N}\).
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

NAVIGATING SCREENS

open access: yesSur: International Journal on Human Rights, 2021
This essay aims to reflect on some of the ways in which security surveillance technology has become politicised through race and gender biases, the product of a historical process known as cis-coloniality.
Mariah Rafaela Silva
doaj  

Private Money as a Competing Medium of Exchange [PDF]

open access: yes
Using a relatively mild restriction on the beliefs of the MMEU-apreference functional, in which the decision maker’s degree of ambiguity and degree of pessimism are each parameterized, we present a rather general theory of religious choice in the ...
Mark Pingle, Sankar Mukhopadhyay
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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