Results 61 to 70 of about 4,846,700 (284)

An approach to anomalies in M-theory via KSpin

open access: yes, 2007
The M-theory fieldstrength and its dual, given by the integral lift of the left hand side of the equation of motion, both satisfy certain cohomological properties.
Buhštaber   +27 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A degree theory for a class of perturbed Fredholm maps

open access: yesFixed Point Theory and Applications, 2005
We define a notion of degree for a class of perturbations of nonlinear Fredholm maps of index zero between infinite-dimensional real Banach spaces. Our notion extends the degree introduced by Nussbaum for locally α-contractive perturbations of the ...
Massimo Furi   +2 more
doaj   +2 more sources

Orientability of Fredholm families and topological degree [PDF]

open access: yes, 1994
We construct a degree theory for oriented Fredholm mappings of index zero between open subsets of Banach spaces and between Banach manifolds. Our approach is based on the orientation of Fredholm mappings: it does not use Fredholm structures on the domain
Fitzpatrick, P.   +2 more
core  

Streamlined subrecursive degree theory

open access: yesAnnals of Pure and Applied Logic, 2012
The paper under review consists of two parts. Part I is devoted to the investigation of the structure of honest elementary degrees, i.e., the degree structure induced on the honest functions by the reducibility relation ``being (Kalmar) elementary in''. In Part II the degree theory found in Part I is generalized.
Kristiansen, Lars   +2 more
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Conceptualizing degrees of theory of mind [PDF]

open access: yesProceedings of the National Academy of Sciences, 2018
Successful navigation of the social world requires making accurate inferences about the contents of other people’s minds, being able to represent in one’s own mind the thoughts, beliefs, and intentions of another. This “theory of mind” (ToM) ability allows us to explain and predict others’ behavior in terms of their mental states (1).
Conway, Jane Rebecca, Bird, Geoffrey
openaire   +6 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Variational inequalities with the duality operator in Banach spaces

open access: yesResults in Nonlinear Analysis, 2020
We study variational inequality by way of metric projection in Banach spaces. The main method is to use a topological degree theory for the class of operators of monotone type in Banach spaces. More precisely, some variational inequality associated with
In-Sook Kim
doaj  

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