Results 81 to 90 of about 4,846,700 (284)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Ambiguity, Pessimism, and Religious Choice [PDF]
Using a relatively mild restriction on the beliefs of the MMEU-apreference functional, in which the decision maker’s degree of ambiguity and degree of pessimism are each parameterized, we present a rather general theory of religious choice in the ...
Mark Pingle, Tigran Melkonyan
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Electronic Journal of Graph Theory and Applications, 2017 In decomposition theory, extreme sets have been studied extensively due to its connection to perfect matchings in a graph. In this paper, we first define extreme sets with respect to degree-matchings and next investigate some of their properties.
Radosław Cymer
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Approximate controllability and regularity for nonlinear differential equations
Advances in Difference Equations, 2011 In this article, we deal with the existence, uniqueness, and a variation of solutions of the nonlinear control system with nonlinear monotone hemicontinuous and coercive operator.
Kim Jin-Ran, Jeong Jin-Mun, Ju Eun-Young
doaj
A Conjecture Regarding the Extremal Values of Graph Entropy Based on Degree Powers
Entropy, 2016 Many graph invariants have been used for the construction of entropy-based measures to characterize the structure of complex networks. The starting point has been always based on assigning a probability distribution to a network when using Shannon’s ...
Kinkar Chandra Das, Matthias Dehmer
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Património Moderno: a conservação e a reutilização como um recurso sustentável
Joelho, 2015 A problemática da intervenção no património moderno não coloca questões estruturalmente diferentes das relativas ao património histórico, na medida em que quando nos referimos a matéria patrimonial falamos de um discurso universal com especificidades ...
Ana Tostões
doaj +1 more source