Results 111 to 120 of about 4,846,700 (284)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
A Geometric Theory for Hypergraph Matching
, 2013 We develop a theory for the existence of perfect matchings in hypergraphs under quite general conditions. Informally speaking, the obstructions to perfect matchings are geometric, and are of two distinct types: 'space barriers' from convex geometry, and '
Keevash, Peter, Mycroft, Richard
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
1-Generic degrees and minimal degrees in higher recursion theory
Japanese journal of mathematics. New series, 1986 The main result of the paper is that for many \(\Sigma_ 2\) inadmissible ordinals, no 1-generic degree bounds a minimal degree. A short description of the current state of study of the structure of 1-degrees in higher recursion theory is also included.
openaire +4 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Edge Degree Weight of Sequential Join of Graphs
Science Journal of University of Zakho, 2013 Let the weight w of an edge e= uv={u,v} of a graph G be defined by w(e)=deg(u)+deg(v)-2 and the weight of G be defined by w(G)= ∑ e ∈ E(G)w(e), where E(G) is the edge set of G.
Khidir R. Sharaf, Didar A. Ali
doaj
Fractional stochastic differential equations and degree theory: a unified perspective
Boundary Value ProblemsThis research focuses on the existence and uniqueness of solutions for a novel class of tempered φ-Caputo stochastic fractional differential equations.
M. Latha Maheswari +2 more
doaj +1 more source
A theory of degrees in education
HeliyonDegrees are presumably the most important institution in education markets. However, despite their high relevance, degrees and their design features remain poorly understood within the economics of education. This study addresses this gap. We provide an accurate formal definition of what constitutes a degree and formulate the first theory of degree ...
Stefan Winter +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source