Inhibition of adenovirus transport from the endosome to the cell nucleus by rotenone [PDF]
Frontiers in Pharmacology, 2023 Regardless of the clinical impact of human adenovirus (HAdV) infections in the healthy population and its high morbidity in immunosuppressed patients, a specific treatment is still not yet available.
María Balsera-Manzanero +12 more
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Deguelin’s Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry [PDF]
Frontiers in PharmacologyDeguelin is a natural isoflavone derived from the rotenone family, commonly found in plants belonging to the Derris and Grifola genera. Comprehensive research has underscored its considerable promise in oncological treatment.
Wenjie Jiang +4 more
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Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice [PDF]
Gut MicrobesAcetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear.
Shenhai Gong +18 more
doaj +4 more sources
Variation in Rotenone and Deguelin Contents among Strains across Four Tephrosia Species and Their Activities against Aphids and Whiteflies [PDF]
Toxins, 2022 Botanical pesticides have received increasing attention for sustainable control of insect pests. Plants from the genus Tephrosia are known to produce rotenone and deguelin.
Peiwen Zhang +5 more
doaj +2 more sources
Prediction of new C-terminal Hsp90 inhibitors based on deguelin scaffold: homology modeling, virtual screening, QM/MM docking, MM/GBSA, and molecular dynamics simulations [PDF]
Research in Pharmaceutical SciencesBackground and purpose: The N-terminal Hsp90 inhibitors are promising targets for cancer treatment; however, inducing the heat shock response is one of the most significant limitations.
Maryam Abbasi +2 more
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In Silico Research of New Therapeutics Rotenoids Derivatives against Leishmania amazonensis Infection [PDF]
Biology, 2022 Yearly, 1,500,000 cases of leishmaniasis are diagnosed, causing thousands of deaths. To advance in its therapy, we present an interdisciplinary protocol that unifies ethnobotanical knowledge of natural compounds and the latest bioinformatics advances to ...
Adrián Vicente-Barrueco +3 more
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Deguelin Restores Paclitaxel Sensitivity in Paclitaxel-Resistant Ovarian Cancer Cells via Inhibition of the EGFR Signaling Pathway [PDF]
Cancer Management and ResearchSeunghee Bae,1 Sowon Bae,1 Hee Su Kim,1 Ye Jin Lim,1 Gyeongmi Kim,2 In-Chul Park,2 Kyeong A So,3 Tae Jin Kim,3 Jae Ho Lee1 1Department of Cosmetics Engineering, Konkuk University, Seoul, 05029, Republic of Korea; 2Division of Fusion Radiology Research ...
Bae S +8 more
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Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway [PDF]
Acta PharmaceuticaDeguelin exhibits antiproliferative activity against various cancer cell types. Previous studies have reported that deguelin exhibits pro-apoptotic activity against human cancer cells. The current study aimed at further elaborating the anticancer effects
Sun Kening +4 more
doaj +3 more sources
An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target [PDF]
Biomedicines, 2020 Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in many cancerous or transformed cells and some stromal cells in the tumor microenvironment ...
Sung-Jun Hong +9 more
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Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat. [PDF]
PLoS ONE, 2012 The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Patrick Paulus +8 more
doaj +5 more sources