Results 21 to 30 of about 1,629 (181)
BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. [PDF]
PLoS ONE, 2016 This study has been undertaken to explore the therapeutic effects of deguelin and specific siRNAs in HeLa cells. The data provided clearly show the silencing of ERK 1/2 with siRNAs and inhibition of ERK1/2 with deguelin treatment in HeLa cells ...
Samra Hafeez +15 more
doaj +1 more source
Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells. [PDF]
PLoS ONE, 2013 Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annually in United States and around the world. Despite advances in the management of patients with this disease, the survival has not been significantly ...
Yan-li Yang +6 more
doaj +1 more source
Mitochondrial DNA mutations in ageing and cancer
Molecular Oncology, Volume 16, Issue 18, Page 3276-3294, September 2022., 2022 Mitochondrial DNA mutations are a common feature of ageing tissues and a number of human cancers. They can affect essential mitochondrial functions such as oxidative phosphorylation, redox balance, apoptosis, and numerous biosynthetic pathways. These are important mechanisms which reportedly impact tumour growth, though data are often contradictory ...
Anna L. M. Smith +2 more
wiley +1 more source
A review on invasive false indigo bush (Amorpha fruticosa L.): Nuisance plant with multiple benefits
Ecology and Evolution, Volume 12, Issue 9, September 2022., 2022 Amorpha fruticosa L. represents an invasive plant causing a nuisance and degrading native biodiversity on a variety of wet and mesic habitats throughout the Northern Hemisphere. On the other hand, the plant species possesses numerous beneficial applications including phytochemical and biocoenotic uses, as well as ecosystem services.
Jasna Grabić +4 more
wiley +1 more source
ChemistryOpen, Volume 11, Issue 5, May 2022., 2022 Ligands selectively targeting DNA G‐quadruplexes (G4s) represent valuable targeted anticancer drugs. Aiming at speeding the identification of G4‐targeting ligands, the affinity chromatography‐based assay named G‐quadruplex on Oligo Affinity Support (G4‐OAS) was developed, by synthesizing G4‐forming sequences on commercial polystyrene OAS.
Chiara Platella +4 more
wiley +1 more source
Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. [PDF]
PLoS ONE, 2016 B-cell chronic lymphocytic leukemia (CLL) remains an incurable disease, and despite the improvement achieved by therapeutic regimes developed over the last years still a subset of patients face a rather poor prognosis and will eventually relapse and ...
Nerea Rebolleda +9 more
doaj +1 more source
Physiologia Plantarum, Volume 174, Issue 2, March/April 2022., 2022 Abstract Seed inoculation with beneficial microorganisms has gained importance as it has been proven to show biostimulant activity in plants, especially in terms of abiotic/biotic stress tolerance and plant growth promotion, representing a sustainable way to ensure yield stability under low input sustainable agriculture. Nevertheless, limited knowledge
Paola Ganugi +9 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, Volume 36, Issue 1, January 2022., 2022 Studying 400 T2DM patients without complication indicated: In T2DM patients without complication, the GPx and TAC levels decreased and the MDA level elevated. T2DM with neuropathy had lower levels of GSH, GPx, and TAC and higher levels of TOS, MDA, and OSI and a higher frequency of Keap1 AA genotype.
Farnaz Khalili +9 more
wiley +1 more source
Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 Cancer is a complex disease with several distinct characteristics, referred to as “cancer markers” one of which is metabolic reprogramming, which is a common feature that drives cancer progression. Over the last ten years, researchers have focused on the reprogramming of glucose metabolism in cancer.
Gui-hua Lai +7 more
wiley +1 more source
A Novel Lysosome-Related Gene Signature Predicts Lung Cancer Prognosis: A Bioinformatics-Driven Study. [PDF]
Health Sci RepABSTRACT Background and Aims The biological function of lysosomes has been increasingly appreciated in cancer. However, the relationship between lysosome and lung adenocarcinoma (LUAD) was not well understood. In this study, a lysosome‐related signature was developed for LUAD risk stratification and prognosis prediction.
Ye W, Sun L, Fu C, Dong H, Zhou T.
europepmc +2 more sources