Results 31 to 40 of about 1,629 (181)

Amelioration of an undesired action of deguelin [PDF]

Toxicon, 2013
The pharmaceutical world has greatly benefited from the well-characterized structure-function relationships of toxins with endogenous biomolecules, such as ion-channels, receptors, and signaling molecules. Thus, therapeutics derived from toxins have been aggressively pursued.
Julie A, Vrana, Nathan, Boggs, Holly N, Currie, Jonathan, Boyd   +3 more
openaire   +2 more sources

Research Status of Mouse Models for Non‐Small‐Cell Lung Cancer (NSCLC) and Antitumor Therapy of Traditional Chinese Medicine (TCM) in Mouse Models

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Non‐small‐cell lung cancer (NSCLC) is known as one of the most lethal cancers, causing more than 1 million deaths annually worldwide. Therefore, the development of novel therapeutic drugs for NSCLC has become an urgent need. Herein, various mouse models provide great convenience not only for researchers but also for the development of antitumor drug ...
Hongkui Chen, Min Zheng, Wenhui Zhang, Yuan Long, Yu Xu, Man Yuan, Atul Kabra   +6 more
wiley   +1 more source

Anthelmintic Agents from African Medicinal Plants: Review and Prospects

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Soil‐transmitted helminthiasis affects more than 1.5 billion people globally and largely remains a sanitary problem in Africa. These infections place a huge economic burden on poor countries and affect livestock production, causing substantial economic losses and poor animal health. The emergence of anthelmintic resistance, especially in livestock, and
Jonathan Jato, Emmanuel Orman, Yaw Duah Boakye, Emelia Oppong Bekoe, Samuel Oppong Bekoe, Samuel Asare-Nkansah, Verena Spiegler, Andreas Hensel, Eva Liebau, Christian Agyare, Harish Chandra   +10 more
wiley   +1 more source

The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Deguelin is a natural rotenoid that shows anti-inflammatory and antimicrobial activities. Rotenoids prevent oxidative damage and potentiate natural antioxidant activity in diabetic conditions, suggesting utility in treating diabetes and ...
Ji Chen, Wenjie Liu, Han Yi, Xiaoling Hu, Liangyu Peng, Fengrui Yang   +5 more
doaj   +1 more source

Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism [PDF]

, 2011
Dihydrotestosterone (DHT) has acute/non-genomic actions in adult mammalian skeletal muscles whose physiological functions are still poorly understood.
Anthony, Avruch, Baird, Barber, Beugnet, Bhasin, Bhasin, Bhasin, Biolo, Bradford, Bruchovsky, Brunet, Christensen, Christensen, Chun, Dann, Deak, Drummond, Drummond, Edmondson, Estrada, Exner, Exner, Ferrando, Ferrando, Franchi-Gazzola, Franchi-Gazzola, Fryburg, Fuller, G. Mutungi, Gazzola, Glass, Hamdi, Harper, Heinlein, Horio, Hyde, Hyde, Hyde, Jiang, Kashiwagi, Kochakian, Krishna, M. M. Hamdi, Mackenzie, McGivan, Mendelsohn, Moule, Mutungi, Palacin, Palii, Pineda, Ravikumar, Regnier, Saartok, Salmons, Schneider-Poetsch, Segawa, Shepherd, Sugawara, Thigpen, Utsunomiya-Tate, Wagner, Wilson, Yao   +64 more
core   +1 more source

Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Pharmacological Research, 2021
Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties. Deguelin, a natural rotenoid, is among the class of bioactive phytoconstituents from a diverse range of plants with potential antineoplastic effects in ...
Hardeep Singh Tuli, Sonam Mittal, Mariam Loka, Vaishali Aggarwal, Diwakar Aggarwal, Akshara Masurkar, Ginpreet Kaur, Mehmet Varol, Katrin Sak, Manoj Kumar, Gautam Sethi, Anupam Bishayee   +11 more
openaire   +2 more sources

Tailor‐Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, Volume 8, Issue 7, April 7, 2021., 2021
This review focuses on the cutting‐edge nanomedicines and nano–bio interactions in the heterogeneous microenvironment of pancreatic ductal adenocarcinoma (PDAC). Herein, this work provides a comprehensive overview of the designed fabrication of PDAC‐tailored functional nanomaterials for laboratory tests, medical imaging, therapy (e.g., chemotherapy ...
Xi Hu, Fan Xia, Jiyoung Lee, Fangyuan Li, Xiaoyang Lu, Xiaozhen Zhuo, Guangjun Nie, Daishun Ling   +7 more
wiley   +1 more source

Natural product inhibitors of ocular angiogenesis [PDF]

, 2014
Natural products are characterized by high chemical diversity and biochemical specificity; therefore, they are appealing as lead compounds for drug discovery.
Basavarajappa, Halesha D., Corson, Timothy W., Sulaiman, Rania S.   +2 more
core   +2 more sources

Deguelin Inhibits the Migration and Invasion of U-2 OS Human Osteosarcoma Cells via the Inhibition of Matrix Metalloproteinase-2/-9 in Vitro

Molecules, 2014
Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung metastasis is the main cause of death in those patients. Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to exhibit cytotoxic
Hung-Sheng Shang, Jin-Biou Chang, Ju-Hwa Lin, Jing-Pin Lin, Shu-Chun Hsu, Chi-Ming Liu, Jia-You Liu, Ping-Ping Wu, Hsu-Feng Lu, Man-Kuan Au, Jing-Gung Chung   +10 more
doaj   +1 more source

Preventative therapies for healthy women at high risk of breast cancer [PDF]

, 2014
Licensed under the Creative Commons Attribution Non-Commercial ...
Sestak, I
core   +3 more sources