Results 41 to 50 of about 60,390 (275)

Migraine and cluster headache show impaired neurosteroids patterns [PDF]

, 2019
Background: Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migraine.
Capi, M., Cicione, C., De Marco, C. M., Di Menna, L., Guglielmetti, M., Koverech, A., Lionetto, L., Maestri, M., Martelletti, P., Negro, A., Nicoletti, F., Passariello, F., Sabbatini, E., Simmaco, M.   +13 more
core   +1 more source

HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma [PDF]

, 2020
Asthma resistance to glucocorticoid treatment is a major health problem with unclear etiology. Glucocorticoids inhibit adrenal androgen production. However, androgens have potential benefits in asthma. HSD3B1 encodes for 3β-hydroxysteroid dehydrogenase-1
Alyamani, Mohammad, Bazeley, Peter, Bleecker, Eugene R., Busse, William W., Calhoun, William J., Castro, Mario, Chung, Kian Fan, Comhair, Suzy, Cotton, Calvin, DeBoer, Mark D., Erzurum, Serpil C., Fahy, John V., Fitzpatrick, Anne M., Gaston, Benjamin, Hawkins, Gregory A., Igo, Robert P., Jr, Israel, Elliot, Jarjour, Nizar N., Levy, Bruce, Marozkina, Nadzeya V., Mauger, David T., Meyers, Deborah, Moore, Wendy C., Noel, Patricia, Ortega, Victor, Patel, Mona, Peters, Stephen P., Sharifi, Nima, Teague, W. Gerald, Wenzel, Sally E., Xu, Weiling, Zein, Joe   +31 more
core   +2 more sources

Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate in Alzheimer's Disease: A Systematic Review and Meta-Analysis

Frontiers in Aging Neuroscience, 2019
Background and Purpose: Previous studies found inconsistent results for the relationship between Alzheimer's disease and the levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate.
Xiongfeng Pan, Xinyin Wu, Atipatsa C. Kaminga, Atipatsa C. Kaminga, Shi Wu Wen, Shi Wu Wen, Aizhong Liu   +6 more
doaj   +1 more source

Steroid hormone levels in postmenopausal hysterectomised women with and without ovarian conservation: the continuous endocrine function of the ovaries

Journal of Obstetrics and Gynaecology, 2023
This study aims to clarify the effect of postmenopausal bilateral oophorectomy on plasma steroid hormone levels. Women who were submitted in the postmenopausal period to hysterectomy for uterine benign conditions were divided into two groups: 18 women ...
Elsa Nunes, Eugenia Gallardo, Sara Morgado-Nunes, José Fonseca-Moutinho   +3 more
doaj   +1 more source

Phosphodiesterase Type 5 Inhibitors, Sport and Doping [PDF]

, 2017
Phosphodiesterase type 5 inhibitors (PDE5i) (e.g., sildenafil, tadalafil, vardenafil, and avanafil) are drugs commonly used to treat erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia.
Borrione, Paolo, CECI GALANOS, Roberta, Crescioli, Clara, Di Luigi, Luigi, Duranti, Guglielmo, Sabatini, Stefania, Sansone, Andrea, Sansone, Massimiliano, Sgrò, Paolo   +8 more
core   +1 more source

Efficacy of dehydroepiandrosterone priming in women with poor ovarian response undergoing IVF/ICSI: a meta-analysis

Frontiers in Endocrinology, 2023
BackgroundDehydroepiandrosterone (DHEA) may improve the outcomes of patients with poor ovarian response (POR) or diminished ovarian reserve (DOR) undergoing IVF/ICSI. However, the evidence remains inconsistent.
Jie Zhang, Hongyan Jia, Hongyan Jia, Feiyang Diao, Xiang Ma, Jiayin Liu, Yugui Cui   +6 more
doaj   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

Dehydroepiandrosterone sulfate (DHEAS) is neuroprotective when administered either before or after injury in a focal cortical cold lesion model [PDF]

, 2006
Dehydroepiandrosterone and its sulfate (DHEAS) are sex hormone precursors that exert marked neurotrophic and/or neuroprotective activity in the central nervous system.
Dobszay B., Gábor, Farkas, Tamás, Juhász-Vedres, Gabriella, Kis, Zsolt, Párducz, Árpád, Rákos, Gabriella, Rózsa, Éva, Toldi, József, Wölfling, János   +8 more
core  

Steroid substrate-induced epimerase mechanism in the active site of the human 11β-hydroxysteroid dehydrogenase type 1 [PDF]

, 2008
Cytochrome P4507B1 7[alpha]-hydroxylates dehydroepiandrosterone (DHEA), epiandrosterone (EpiA) and 5[alpha]-androstane-3[beta],17[beta]-diol (Adiol). 11[beta]-Hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) interconverts 7[alpha]- and 7[beta]- forms.
Alain Favre-Reguillon, Clotilde Ferroud, Henry Chermette, Matthieu Montes, Olivier Hennebert, Robert Morfin   +5 more
core   +2 more sources

Methylglyoxal-dependent glycative stress and deregulation of SIRT1 functional network in the ovary of PCOS mice [PDF]

, 2020
Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female infertility.
Amicarelli, F, Cristiano, L, D'Alessandro, AM, Emidio, GD, Falone, S, Nottola, S, Palmerini, MG, Placidi, M, Rea, F, Rossi, G, Tatone, C   +10 more
core   +1 more source